Results 61 to 70 of about 4,260,168 (338)
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Frontiers in Public HealthLaboratories play a central role in managing public health emergencies. The COVID-19 pandemic imposed unique challenges on global laboratory systems, including testing protocol uncertainties, supply shortages, rapid need for information dissemination ...
Céline Barnadas +6 more
doaj +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Models of Collaborative Remote Laboratories and Integration with Learning Environments
International Journal of Online Engineering (iJOE), 2016 Development of remote laboratories in academic settings has been held back because of the lack of standardization of technology, processes, operation and their integration with formal educational environments.
L. F. Rivera +1 more
semanticscholar +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Transformations in the governance of French medical laboratories
Revue de la RégulationIn France, private medical laboratories (PMLs) were at the heart of the fight against the Covid-19 pandemic. Each year biological examinations account for over 70 % of all medical diagnoses. Although the health crisis put the spotlight on this sector, no
Antoine Leymarie
doaj +1 more source
Review and comparison of quality standards, guidelines and regulations for laboratories
African Journal of Laboratory Medicine, 2011 Background: The variety and number of laboratory quality standards, guidelines and regulations (hereafter: quality documents) makes it difficult to choose the most suitable one for establishing and maintaining a laboratory quality management system ...
Tjeerd A.M. Datema +2 more
doaj +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Preparing medical laboratories in low- and middle-income countries for a sustainable future
African Journal of Laboratory MedicineNot applicable.
Tony Badrick, John Anetor
doaj +1 more source