Results 21 to 30 of about 1,548,442 (139)

Identificationof a novel linear epitope on the porcine reproductive and respiratory syndrome virus nucleocapsid protein, as recognized by a specific monoclonal antibody

Frontiers in Immunology, 2023
IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV) remains one of the most threatening pathogens of swine. The nucleocapsid (N) protein is the major structural protein of the virus and has been used as a PRRSV diagnostic antigen due ...
Yuening Cheng, Miaoli Wu, Li Xiao, Mengdi Zhang, Bihong Huang, Feng Cong, Li Yi   +6 more
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Isolation and characterization of Bordetella pseudohinzii in mice in China

Animal Models and Experimental Medicine, 2019
We report on the first detection and isolation of B. pseudohinzii (Bordetella pseudohinzii) in laboratory mice in China. Forty‐one B. pseudohinzii strains were isolated from 3094 mice in 33 different laboratory animal facilities in southern China.
Lei Ma, Shuwu Huang, Yinzhu Luo, Fangui Min, Lifang He, Meiling Chen, Jinchun Pan, Yu Zhang, Jing Wang   +8 more
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Prediction of Compound Synthesis Accessibility Based on Reaction Knowledge Graph

Molecules, 2022
With the increasing application of deep-learning-based generative models for de novo molecule design, the quantitative estimation of molecular synthetic accessibility (SA) has become a crucial factor for prioritizing the structures generated from ...
Baiqing Li, Hongming Chen
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Establishment and evaluation of a transgenic mouse model of arthritis induced by overexpressing human tumor necrosis factor alpha

Biology Open, 2016
Tumor necrosis factor alpha (TNFα) plays a key role in the pathogenesis of rheumatoid arthritis (RA). Blockade of TNFα by monoclonal antibody has been widely used for the therapy of RA since the 1990s; however, its mechanism of efficacy, and potential ...
Ge Li, Yu'e Wu, Huanhuan Jia, Lu Tang, Ren Huang, Yucai Peng, Yu Zhang   +6 more
doaj   +1 more source

Multiplex Detection of Five Canine Viral Pathogens for Dogs as Laboratory Animals by the Luminex xTAG Assay

Frontiers in Microbiology, 2018
More and more dogs have been used as a disease model for medical research and drug safety evaluation. Therefore, it is important to make sure that the dogs and their living houses are special pathogen free.
Miaoli Wu, Miaoli Wu, Feng Cong, Yujun Zhu, Yuexiao Lian, Meili Chen, Ren Huang, Pengju Guo   +7 more
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Systemic Candida parapsilosis Infection Model in Immunosuppressed ICR Mice and Assessing the Antifungal Efficiency of Fluconazole

Veterinary Medicine International, 2015
This study was to establish a systemic C. parapsilosis infection model in immunosuppressed ICR mice induced by cyclophosphamide and evaluate the antifungal efficiency of fluconazole. Three experiments were set to confirm the optimal infectious dose of C.
Yu’e Wu, Fangui Min, Jinchun Pan, Jing Wang, Wen Yuan, Yu Zhang, Ren Huang, Lixin Zhang   +7 more
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General Anesthetics Commonly Used for Laboratory Animals

Shiyan dongwu yu bijiao yixue, 2022
General anesthetics used for laboratory animals are mostly controlled drugs, and are subject to strict supervision by the competent government agency in China.
LU Xiao, YU Lingzhi, CHOU Sonja Tsung-Ying, LI Ruying, CHEN Wenjun, JIANG Shanxiang   +5 more
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Alternatives to Carbon Dioxide—Taking Responsibility for Humanely Ending the Life of Animals

Animals, 2019
Carbon dioxide (CO2) is commonly used to kill rodents. However, a large body of research has now established that CO2 is aversive to them. A multidisciplinary symposium organized by the Swiss Federal Food Safety and Veterinary Office discussed the ...
Shannon Axiak Flammer, Chantra Eskes, Ingrid Kohler, Awilo Ochieng Pernet, Peter Jakob, Michael Marahrens, Thomas C. Gent, Huw Golledge, Dan Weary   +8 more
doaj   +1 more source

Dynamics of Immune Responses during Experimental Mycobacterium kansasii Infection of Cynomolgus Monkeys (Macaca fascicularis)

Mediators of Inflammation, 2018
To profile the dynamic changes of immune responses for M. kansasii infection, 3 cynomolgus monkeys were experimentally infected with M. kansasii by intratracheal inhalation of 1 × 106 CFU bacteria per monkey. Every 2 to 4 weeks, tuberculin skin testings (
Fangui Min, Lifang He, Yinzhu Luo, Shuwu Huang, Jinchun Pan, Jing Wang, Ruike Wu, Lan Zhang, Meili Chen   +8 more
doaj   +1 more source

Protection of animals used in experiments in Polish law - history, present day and perspective: a review

Veterinární Medicína, 2014
The aim of EU legislators with respect to experiments on animals was to reduce to an absolute minimum both the number of animals used in experiments and their suffering.
M.Z. Felsmann, J. Szarek, M. Felsmann, E. Strzyzewska   +3 more
doaj   +1 more source