Results 81 to 90 of about 1,536,423 (242)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Characterization of Intor:Swiss Albino Mice Adopted in the Institute of Virology, Vaccines and Sera – Torlak, Belgrade in the Early Twentieth Century

Acta Veterinaria, 2016
The Institute of Virology, Vaccines and Sera Torlak was established in 1927, while the first vaccine was produced in the Institute in 1930. Vaccines production implies using experimental animals, including mice, in in-process controls.
Živković Irena, Rajnpreht Irena, Minić Rajna, Mitić Katarina, Aleksić Iva, Kadrić Jasminka, Petrušić Vladimir   +6 more
doaj   +1 more source

Is the risk of developing atopic sensitization and bronchial asthma in animal laboratory workers preventable in well-defined susceptible individuals? [PDF]

, 2017
Gennaro Liccardi, Luigino Calzetta, A Barrile, Federica Maria Giorgino, Carmine Sapio, Paola Rogliani   +5 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A New Way to Model Periodontitis in Laboratory Animals. [PDF]

Dent J (Basel), 2023
Moiseev D, Donskov S, Dubrovin I, Kulyukina M, Vasil'ev Y, Volel B, Shadieva S, Babaev A, Shevelyuk J, Utyuzh A, Velichko E, Dydykin S, Dydykina I, Paramonov Y, Faustova E.   +14 more
europepmc   +1 more source

Toxigenic Profile ofClostridium perfringensStrains Isolated from Natural Ingredient Laboratory Animal Diets

, 2022
Michael D Johnston, Tanya E Whiteside, Michelle E Allen, David M Kurtz   +3 more
openalex   +2 more sources

Anti-inflammatory, hypoglycemic and hypolipidemic effects of Stevia rebaudiana bertoni leaf extract in an experimental model of diabetes mellitus and obesity in laboratory animals [PDF]

, 2021
Irina I. Novikova, Aleksandr S. Ogudov, I. G. Shevkun, E. V. Serenko, N. F. Chuenko, Stepan Mikhailovich Gavrish, M. V. Semenikhina, N. Yu. Kryuchkova   +7 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

GnRH-driven FTO-mediated RNA m6A modification promotes gonadotropin synthesis and secretion

BMC Biology
Background Gonadotropin precisely controls mammalian reproductive activities. Systematic analysis of the mechanisms by which epigenetic modifications regulate the synthesis and secretion of gonadotropin can be useful for more precise regulation of the ...
Hao-Qi Wang, Yi-Ran Ma, Yu-Xin Zhang, Fan-Hao Wei, Yi Zheng, Zhong-Hao Ji, Hai-Xiang Guo, Tian Wang, Jia-Bao Zhang, Bao Yuan   +9 more
doaj   +1 more source