Results 71 to 80 of about 404,776 (250)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Leptospirosis in the United Kingdom: a decade of experience from a large regional hospital
Travel Medicine and Infectious DiseaseBackground: Leptospirosis is one of the most common bacterial zoonoses worldwide, with a broad spectrum of illness from mild and self-resolving to multi-organ failure and death.
Andrew Taylor +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
DEVELOPMENT OF A METHOD FOR LABORATORY DIAGNOSTICS OF ACUTE HYPOTENSIVE DRUGS POISONING
Сеченовский вестник, 2012 The method of express detection of hypotensive drugs (atenolol, propranolol, nifedipine, enalaprile and verapamil) in urine samples of patients with acute poisonings was developed. The optimum conditions of group identification of hypotensive drugs using
E. S. Melnikov, M. V. Belova
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Laboratory diagnostics of inherited platelet disorders
Clinical Chemistry and Laboratory Medicine (CCLM), 2014 Abstract Inherited platelet disorders (IPDs) are the general and common denomination of a broad number of different rare and congenital pathologies affecting platelets. Even if these disorders are characterized by widely heterogeneous clinical presentations, all of them are commonly present as defects in hemostasis.
CARUBBI, Cecilia +7 more
openaire +6 more sources
Acta Biomedica Scientifica, 2015 Leptospirosis is a cosmopolitan natural-focal disease representing a serious problem for the majority of the countries in the world including the Russian Federation because this infection causes a serious economic and social damage.
Ye. Yu. Kiseleva +5 more
doaj
Clinical laboratory diagnostics of immunosuppressants: One laboratory’s journey
Proceedings of Singapore Healthcare, 2015 Laboratory support for the organ transplant patient is the provision of the best testing technology for a specific and accurate determination of immunosuppressive drug level.
Wai Yoong Ng, Chin Pin Yeo
doaj +1 more source
Studia Ecologiae et Bioethicae, 2008 The need to establish the Code of Ethics of a Laboratory Diagnostician stems from the development of medicine in which the specialized laboratory diagnostics has been playing an increasingly important role.
Kazimierz Szałata
doaj +1 more source