Results 81 to 90 of about 2,725,465 (255)

Impact of the use of self-perceived gender identity versus biological gender on the interpretation of laboratory tests: clinical and safety implications intransgender individuals

Critical Public Health
Laboratory medicine relies on sex-specific reference ranges for accurate interpretation. However, electronic records often register legal or self-identified gender, which may not reflect biological sex.
Francisco J. Mérida, Soledad Sánchez-Moreno Montes, Dana Díaz-Canales, Javier Porta-Pelayo, Eva Moreno-Campoy   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Use of artificial intelligence technologies in laboratory medicine, their effectiveness and application scenarios: a systematic review

Digital Diagnostics
BACKGROUND: With the increasing volume of data, laboratory medicine requires automation and standardization of routine processes to reduce workload on healthcare professionals and clear their time for more specialized tasks.
Yuriy A. Vasilev, Olga G. Nanova, Anton V. Vladzymyrskyy, Arcadiy S. Goldberg, Ivan A. Blokhin, Roman V. Reshetnikov   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Errors in laboratory specimen using barcode system

Journal of Health Science and Medical Research (JHSMR), 2009
Objective: To evaluate errors of specimens sending from in-patient department and emergency room, Songklanagarind Hospital after adopting online requests and barcode system.
P Kongthong, P Thongsuksai, P Rengrairattanarose, P Boonyaphiphat, P Chusongsang, P Apirakthunyakorn   +5 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Laboratory Medicine

BioMed Research International, 2013
Hur, Mina, John, Andrew St., La Gioia, Antonio   +2 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Measuring the Prevalence of Microcytosis of Red Blood Cells Among Different Pediatric Age Groups. A Retrospective Study.

Journal of Medicine in Scientific Research
Aim: Detect the prevalence of microcytosis of red blood cells (RBCs) and pattern of morphological classification of anemia among different paediatric age groups during their visit to the out-patient clinics in the hospital.
Sarah Mohammad Atef Mostafa, Mary Shaker Zakher Gerges   +1 more
doaj   +1 more source