Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Direct Acceleration of an Electron Beam with a Radially Polarized Long-Wave Infrared Laser
PhotonicsDirect laser acceleration with radially polarized lasers is an intriguing variant of laser-based particle acceleration that has the potential of offering GeV/cm-level energy while avoiding the instabilities and complex beam dynamics associated with ...
William H. Li +2 more
doaj +1 more source
Evaluation of the Sigma Quality level for Serum Iron determination by two colorimetric methods, Ferrozine and Ferene S [PDF]
, 2019 Iron plays important functions in the body such as the formation and functioning of hemoglobin and it’s disorders are among the most common diseases of human1.
Faria, Ana Paula +3 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Structural and Optical Properties of Amorphous Al2O3 Thin Film Deposited by Atomic Layer Deposition
Advances in Condensed Matter Physics, 2018 Aluminum oxide (Al2O3) amorphous structure with short-range order and long-range disorder has presented promising applications in optical and optoelectronic devices.
Shuzheng Shi +5 more
doaj +1 more source
COMPETENCY ENHANCEMENT MICROBIOLOGY TESTING OF FISH QUARANTINE LABORATORY OFFICHER AT FISH QUARANTINE AND INSPECTION AGENCY, QUALITY CONTROL, AND SAFETY OF FISHERY PRODUCT THROUGH EDUCATION AND TRAINING [PDF]
, 2013 The pace of globalization is increasingly apparent demanding technological advances in all fields. Government officials serve as the subject of development practitioners have the required competence.
Yahya, Tri Laksana
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Scientific ReportsEpilepsy is a neurological disorder characterized by recurrent seizures caused by excessive electrical discharges in brain cells, posing significant diagnostic and therapeutic challenges.
Kunxian Yan +11 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Space shuttle engineering and operations support. Avionics system engineering [PDF]
The shuttle avionics integration laboratory (SAIL) requirements for supporting the Spacelab/orbiter avionics verification process are defined. The principal topics are a Spacelab avionics hardware assessment, test operations center/electronic systems ...
Broome, P. A. +2 more
core +1 more source