Results 71 to 80 of about 6,229,843 (307)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

MXene-based functionalized platforms for high-performance MALDI-TOF MS: application in early-stage bloodstream infection biomarker screening

Frontiers in Bioengineering and Biotechnology
Introduction This study developed a MALDI-TOF MS metabolomics analysis method based on MXene nanomaterial functionalization platform for early diagnosis of bloodstream infections (BSI).
Wenjia Quan, Yingpo Qiu, Lv Yang, Hao Wang   +3 more
doaj   +1 more source

Study of an instrument for sensing errors in a telescope wavefront [PDF]

Focal plane sensors for determining the error in a telescope wavefront were investigated. The construction of three candidate test instruments and their evaluation in terms of small wavefront error aberration measurements are described.
Golden, L. J., Shack, R. V., Slater, P. N.   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

An arc tangent function demodulation method of fiber-optic Fabry-Perot high-temperature pressure sensor

Photonic Sensors, 2017
A new demodulation algorithm of the fiber-optic Fabry-Perot cavity length based on the phase generated carrier (PGC) is proposed in this paper, which can be applied in the high-temperature pressure sensor. This new algorithm based on arc tangent function
Qianyu Ren, Junhong Li, Yingping Hong, Pinggang Jia, Jijun Xiong   +4 more
doaj   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Flexible wide-range multidimensional force sensors inspired by bones embedded in muscle

Microsystems & Nanoengineering
Flexible sensors have been widely studied for use in motion monitoring, human‒machine interactions (HMIs), personalized medicine, and soft intelligent robots.
Jie Zhang, Xiaojuan Hou, Shuo Qian, Jiabing Huo, Mengjiao Yuan, Zhigang Duan, Xiaoguang Song, Hui Wu, Shuzheng Shi, Wenping Geng, Jiliang Mu, Jian He, Xiujian Chou   +12 more
doaj   +1 more source

A 2000-hour cyclic endurance test of a laboratory model multipropellant resistojet [PDF]

The technological readiness of a long-life multipropellant resistojet for space station auxiliary propulsion is demonstrated. A laboratory model resistojet made from grain-stabilized platinum served as a test bed to evaluate the design characteristics ...
Morren, W. Earl, Sovey, James S.
core   +1 more source