Results 41 to 50 of about 1,980,146 (314)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Promoting fair globalization in textiles and clothing in a post-MFA environment [PDF]
, 2005 The working paper reports on the current trade conditions in the textile clothing industry in the post Multifibre Agreement era. Additionally, the paper advocates for a fairer globalization, promoting better work conditions, labor wages and general ...
International Labour Office
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Global Employment Trends for Youth: October 2008 [PDF]
, 2008 [Excerpt] An intensified focus on youth at the international level in recent years has brought a greater understanding of youth labour markets and led to development of a growing number of national action plans for youth employment as well as other more ...
International Labour Office
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Child Labour in Latin America [PDF]
, 2005 Fact sheet on child labor in Latin America, compiled by the International Labour Organization (ILO) in ...
International Labour Organization
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Abordări privind îngrijirea de lungă durată a persoanelor vârstnice, în ţările Uniunii Europene
Sociologie Românească, 2020 This paper presents an analysis of the characteristics of public policies for dependent elderly people in Germany, Austria, Italy, Hungary and Portugal. The countries were selected taking into account the expertise in this field and the specifics of the ...
Mihaela Ghenţa +2 more
doaj +1 more source
Forced labour and migration to the UK [PDF]
, 2005 No description ...
Anderson, Bridget, Rogaly, Ben
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source