Results 51 to 60 of about 915,737 (313)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Digital Labour Markets in Central and Eastern European Countries
, 2023 This book examines the impact of the COVID-19 pandemic on changing labour markets and accelerating digitalisation of the workplace in Central and Eastern Europe.
core +2 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Dilemmas of human potential management, from the viewpoint of employment security
Management, 2016 In this study - based on the result of own and others empirical research, regarding conditions of person’s functioning in the process of work during the last decade of 2000’s - an attempt of indicating dilemmas connected with shaping of employment ...
Bodak Andrzej +4 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Quality of work for Syrian refugees in Jordan
Forced Migration Review, 2018 Work permits have been at the centre of the policy debate on the hosting of Syrian refugees in Jordan. This approach needs also to involve ensuring decent working conditions for all.
Maha Kattaa, Meredith Byrne
doaj
Trends in Policy on the Prevention and Control of Non-Communicable Diseases in Japan
Health Systems & Reform, 2017 —For the past decades Japan has remained number one in a range of population health metrics including the world's longest healthy life expectancy. While this was achieved through various socioeconomic factors besides public health interventions, health ...
Satoshi Ezoe +11 more
doaj +1 more source
For socialism and peace : the Labour Party's programme of action.
, 1934 Cover title: For socialism and peace : programme of the Labour Party.; Includes bibliographical references.; Electronic reproduction. Canberra, A.C.T.
Labour Party (Great Britain)
core