Results 41 to 50 of about 2,166,566 (364)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

2007 Labour Overview: Latin America and the Caribbean [PDF]

, 2008
[Abstract] In summary, as the 2007 Labour Overview which I am pleased to present demonstrates, Latin America and the Caribbean have made progress in improving some key labour market indicators, especially in reducing unemployment, but significant gaps ...
International Labour Office
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Review of: "Comparative Study between Using Only Vaginal Misoprostol and Using Vaginal Misoprostol and Estradiol Cream for Induction of Labour: Randomized controlled trial" [PDF]

, 2022
Justin C. Konje
openalex   +1 more source

Global Employment Trends [PDF]

, 2006
The January 2006 report documents the current trend in Global employment as well as the effects of the Asian tsunami, migration, and the oil shock in ...
International Labour Office
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Global Employment Trends for Youth [PDF]

, 2006
[Excerpt] Young women and men are among the world’s greatest assets. They bring energy, talent and creativity to economies and create the foundations for future development.
International Labour Office
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Abordări privind îngrijirea de lungă durată a persoanelor vârstnice, în ţările Uniunii Europene

Sociologie Românească, 2020
This paper presents an analysis of the characteristics of public policies for dependent elderly people in Germany, Austria, Italy, Hungary and Portugal. The countries were selected taking into account the expertise in this field and the specifics of the ...
Mihaela Ghenţa, Aniela Matei, Luise Mladen-Macovei   +2 more
doaj   +1 more source

Training Policies for Vulnerable Groups in Central and Eastern European Countries [PDF]

, 2003
[From Preface] Since 1989, the countries of Central and Eastern Europe have faced both challenges and opportunities in the field of human resource development.
International Labour Office
core   +1 more source