Results 251 to 260 of about 55,363 (313)

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Membranous Labyrinth Position in the Lateral Semicircular Canal: Considerations for Gene Therapy Delivery. [PDF]

OTO Open
Lakpa KL, Matabele MN, da Costa Monsanto R, Falcioni M, Keskin-Yilmaz N, Miller B, Mierzwinski J, Rivera A, Dahl JP, Fishman AJ, Cureoglu S, Puricelli MD.   +11 more
europepmc   +1 more source

Progress On Sensorineural Hearing Loss: Mechanisms and Therapies

Sensory Neuroscience, EarlyView.
ABSTRACT Hearing loss is the most common disabling disease among humans, which adversely affects human health. Sensorineural hearing loss (SNHL) accounting for approximately 63% of all hearing loss cases. SNHL may be classified into age‐related hearing loss (ARHL), drug‐induced hearing loss (DIHL), noise‐induced hearing loss (NIHL), and sudden ...
Yuan Zhang, Shen Li, Yangfan Zhou, Duopin Li, Junru Ding, Ruifeng Qiao, Yutian Chen, Fanglei Ye, Le Wang, Peipei Li   +9 more
wiley   +1 more source

miR-155 suppresses angiotensin II type 1 receptor synthesis during placental morphogenesis. [PDF]

Cell Death Discov
Arthurs AL, Lumbers ER, Schofield L, Lees C, Chin PY, Care AS, Robertson SA, Schjenken JE, Pringle KG.   +8 more
europepmc   +1 more source

AMPKα Silencing Prevents Kanamycin‐Induced Ototoxicity in an Acute Mouse Model

Sensory Neuroscience, EarlyView.
Kanamycin plus furosemide (KM + FU) treatment (acute ototoxic model) causes AMPKα activation and rapidly induces cochlear outer hair cell (OHC) loss. Silencing AMPKα1 via posterior semicircular canal injection 48 h before KM + FU treatment reduces this damage, preserving OHCs and hearing.
Shengyu Zou, Fan Wu, Qiaojun Fang, Zuhong He, Hongguo Su, Shan Xu, Su‐Hua Sha   +6 more
wiley   +1 more source

Spatiotemporal characterization of placental hypoxia and microvascular dysfunction in a preeclampsia rat model using photoacoustic and contrast-enhanced ultrasound. [PDF]

Quant Imaging Med Surg
Zhang B, Pang H, Yang H, Luo H.
europepmc   +1 more source

Brain‐Inspired Neuromorphic Device for Artificial Intelligent Robots Applications

SmartBot, EarlyView.
Brain‐inspired neuromorphic devices mimic biological systems to provide an efficient hardware foundation for embodied intelligent robotics. This review explores the material systems and corresponding computing architectures of neuromorphic devices that support low‐power perception, adaptive learning, and real‐time decision‐making.
Jiachen Han, Zheng Wang, Tianyu Wang, Jialin Meng   +3 more
wiley   +1 more source

Tim1 Deficiency Mediates Gestational Hyperglycemia-Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction. [PDF]

Adv Sci (Weinh)
She J, Liu R, Fang C, Zhang S, Hu Y, Guo F, Long Y, Ding M, Wu H, Zhou B, Yang Z, Jiang Y, Sheng J, Gao L, Huang H.   +14 more
europepmc   +1 more source

A Prodrug Approach for Activity‐Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer's Disease

Small, EarlyView.
We present a pathology‐responsive, activity‐based prodrug strategy that tackles multiple hallmarks of Alzheimer's disease (AD). Rationally designed BE compounds convert under oxidative stress into redox‐active aminophenols, neutralizing ROS and redirecting both metal‐free and metal‐bound Aβ aggregation.
Jimin Lee, Eunseo Hong, Chanju Na, Yan Li, Jun Go, Ju‐Eun Kim, Hyun‐Hee Seo, Jong‐Min Suh, Jimin Kwak, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Mingeun Kim, Mi Hee Lim   +13 more
wiley   +1 more source

A Case of Calcification Discovered Within the Membranous Labyrinth During Resection of a Vestibular Schwannoma. [PDF]

Otol Neurotol
Ahmad SA, Zawitoski H, Hiel H, Balhi Y, Lauer A, Kaufman A, Ward BK.   +6 more
europepmc   +1 more source