Results 61 to 70 of about 144,453 (302)

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Visual Fixation and Continuous Head Rotations Have Minimal Effect on Set-Point Adaptation to Magnetic Vestibular Stimulation

Frontiers in Neurology, 2019
Background: Strong static magnetic fields such as those in an MRI machine can induce sensations of self-motion and nystagmus. The proposed mechanism is a Lorentz force resulting from the interaction between strong static magnetic fields and ionic ...
Bryan K. Ward, David S. Zee, David S. Zee, David S. Zee, David S. Zee, Dale C. Roberts, Dale C. Roberts, Michael C. Schubert, Michael C. Schubert, Nicolas Pérez-Fernández, Jorge Otero-Millan   +10 more
doaj   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Membrane Stress Proclivities in the Mammalian Labyrinth

International Archives of Otorhinolaryngology, 2014
Introduction The membranes of the inferior division of the labyrinth in some mammals appear more vulnerable to hydropic distention than those of the superior division.
Daniel J. Pender
doaj   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Per insegnare la filosofia on-line: suggestioni platoniche e questioni didattiche

Journal of Educational, Cultural and Psychological Studies, 2017
On teaching philosophy on-line: platonic suggestions and pedagogical issues. The debate about the problems inherent the usage of the tools employed for an effective transmission of the philosophical message are extremely ancient. Plato’s hesitation when 
Angela Arsena
doaj   +1 more source

On certain families of planar patterns and fractals

, 2017
This survey article is dedicated to some families of fractals that were introduced and studied during the last decade, more precisely, families of Sierpi\'nski carpets: limit net sets, generalised Sierpi\'nski carpets and labyrinth fractals.
Cristea, Ligia L.
core   +1 more source

Nature‐Inspired Surface Modification Strategy Reverses the Autophagic Flux Impairment of Mitochondrial Transplantation for Attenuating Ischemic Strokes

Advanced Science, EarlyView.
The functionalized starch modifies the mitochondrial surface and encapsulates resveratrol into the cavity of helices, facilitating a novel mitochondrial transplantation platform (MLSR). Upon internalization in recipient cells, MLSR triggers mitophagy and maintains positive autophagic flux through RIP1/RIP3 pathway inhibition.
Nisha Wang, Qiyang Ding, Lei Shi, Ji Xia, Shuyue Zhang, Chenxin Jian, Yixiao Yan, Xiuhua Luo, Jiarui Wang, Ming Cheng, Yiqiong Jia, Hao Tian, Wei Gao   +12 more
wiley   +1 more source

Structural Optimization of Labyrinth Screw Pump Based on Response Surface Model

Shiyou jixie, 2022
The labyrinth screw pump is deficient for low efficiency. In this paper, a structural optimization model of labyrinth screw pump was established based on experimental design and response surface estimation, with the efficiency, shaft power and head of ...
Rong Xin, Zhu Hongwu
doaj  

The Metaphors of Quests, Labyrinths and the Dance of Kali in Christopher Koch’s The Year of Living Dangerously

eTropic: electronic journal of studies in the tropics, 2002
Ovid’s myth of the Cretan labyrinth, constructed by Daedalus to hide the Minotaur, the monster that is a result of Pasiphae’s lust, and Dante’s labyrinth of Hell, in The Inferno, are literary allusions that conjure images of imprisonment and moral ...
Sathyabhama Daly
doaj   +1 more source