Results 71 to 80 of about 62,770 (310)

Ototoxicidade por organofosforados: descrição dos aspectos ultraestruturais do sistema vestibulococlear de cobaias Organophosphate-related ototoxicity: Description of the vestibulocochlear system ultrastructural aspects of guinea pigs

open access: yesBrazilian Journal of Otorhinolaryngology, 2010
Os agrotóxicos organofosforados são amplamente utilizados na agricultura, e atualmente fazem parte do grupo de agentes químicos que podem levar à perda auditiva, no qual já estavam incluídos os solventes, os metais e os asfixiantes.
Daiane Körbes   +3 more
doaj   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li   +15 more
wiley   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

open access: yesAdvanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao   +7 more
wiley   +1 more source

REACTIONS OF THE LABYRINTH AND THEIR SIGNIFICANCE IN THE DIAGNOSIS OF SUPPURATIVE LABYRINTHITIS. [PDF]

open access: yesJournal of the American Medical Association, 1908
Although, since the time of Purkinje, vertigo from turning was known, and since the time of Florens, vertigo from syringing the ear with cold water has been frequently observed, it remained for Mach, Breuer and Ewald to note that vertigo is associated with nystagmus in man and with head rolling and nystagmus in animals.
openaire   +2 more sources

Augustine Tower labyrinth

open access: yes, 2018
St Augustine's Tower, Hackney. Creating and walking a cross-shaped 'stepping stone' temporary labyrinth on the footprint of a lost church.
Penfold, E., Overall, S.
core  

Labyrinth Weirs [PDF]

open access: yes, 2010
Labyrinth weirs are often a favorable design option to regulate upstream water elevations and increase flow capacity; nevertheless, it can be difficult to engineer an optimal design due to the complex flow characteristics and the many geometric design ...
Crookston, Brian Mark
core   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

open access: yesAdvanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang   +12 more
wiley   +1 more source

Labyrinth Stimulation [PDF]

open access: yesThe Journal of Nervous and Mental Disease, 1919
n ...
openaire   +1 more source

Labyrinth

open access: yes, 2015
01 Labyrinth of the World 2015 drape, embroidered cryptogram & generative videoscape accessed via Augmented reality drape size: 180 x 120 cm video: 51 sec colour: audio 02 Searchall Ubiquitous 2015 drape, embroidered cryptogram & generative ...
Mauro-Flude, MN (15584000)
core  

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

open access: yesAdvanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li   +9 more
wiley   +1 more source

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