Results 111 to 120 of about 19,094 (297)

Executive dysfunction and employment in epilepsy

Epilepsia, EarlyView.
Abstract Objective Executive dysfunction, affective symptoms, and unemployment are prevalent in patients with epilepsy, yet the relation between these variables remains poorly understood. The present study examined: (1) The relationship between epilepsy‐related variables, affective symptoms, and executive functions (EFs); and (2) how these variables ...
Lisa E. Hauger, Christoph Helmstaedter, Morten I. Lossius, Kristin Å. Alfstad, Ellen Molteberg, Halvor Torgersen, Annette H. Skogan   +6 more
wiley   +1 more source

Management of labyrinthine fistula: hearing preservation versus prevention of residual disease

, 2017
The objective of the study was to evaluate postoperative hearing and disease control after cholesteatoma surgery for labyrinthine fistulas. In a retrospective cohort study, we evaluated a consecutive cohort comprising 44 patients (45 ears) with ...
Geerse, S., de Wolf, M. J. F., Ebbens, F. A., van Spronsen, E.   +3 more
core   +1 more source

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

Treatment of infantile labyrinth diseases with flunarizine

, 1989
ESCOLA PAULISTA MED SCH,DISC OTORRINGOL,SETOR EQUILIBRIOMETRIA,BR-04023 SAO PAULO,SP,BRAZILESCOLA PAULISTA MED SCH,DISC OTORRINGOL,SETOR EQUILIBRIOMETRIA,BR-04023 SAO PAULO,SP,BRAZILWeb of ...
Ganança, Fernando Freitas [UNIFESP], Moreira, Elizabet, Ganança, Mauricio Malavasi [UNIFESP], Ito, Yasuko Imasato [UNIFESP], Lemos, Marisa, Caovilla, Heloisa Helena [UNIFESP], Saltini, Claudia   +6 more
core  

Placental-Specific Overexpression of sFlt-1 Alters Trophoblast Differentiation and Nutrient Transporter Expression in an IUGR Mouse Model

, 2017
Since it is known that placental overexpression of the human anti-angiogenic molecule sFlt-1, the main candidate in the progression of preeclampsia, lead to intrauterine growth restriction (IUGR) in mice by lentiviral transduction of mouse blastocysts ...
Gellhaus, Alexandra, Winterhager, E., Herse, Florian, Kaiser, S., Violeta Stojanovska, Ploesch, T., Kuehnel, Elisabeth, Stephanie Kaiser, Torsten Plösch, Kuehnel, E., Herse, F., Veronika Kleff, Stojanovska, Violeta, Ralph Waldschütz, Florian Herse, Waldschuetz, Ralph, Kaiser, Stephanie, Kleff, Veronika, Plosch, Torsten; id_orcid, Alexandra Gellhaus, Plosch, Torsten, Elisabeth Kühnel, Waldschuetz, R., Kleff, V., Winterhager, Elke, Gellhaus, A., Stojanovska, V., Elke Winterhager   +27 more
core   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

DNA methylation inhibitors adverse reaction characteristic analysis: a descriptive analysis from WHO-VigiAccess

Frontiers in Pharmacology
IntroductionDNA methylation inhibitors (azacitidine, decitabine) have revolutionized the treatment dilemma of myelodysplastic syndromes (MDS), a group of malignant hematopoietic disorders.
Qiang Zhou, Quanlei Xie, Qiang Liu, Haojie Wang, Zhan Zhang, Zhao Yu, Qian Guo, Jie Lin   +7 more
doaj   +1 more source

Placental contribution to nutritional programming of health and diseases: epigenetics and sexual dimorphism

, 2014
International audienceThe recent and rapid worldwide increase in noncommunicable diseases challenges the assumption that genetic factors are the primary contributors to such diseases.
Gabory, Anne, Ferry, Laure, L., Panchenko, Polina, Junien, Claudine, C.   +3 more
core  

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (KI) mouse model of LGS by quantifying atypical absence seizures and epileptic spasms and ...
Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold   +5 more
wiley   +1 more source