Results 91 to 100 of about 2,149,670 (310)

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

XV. Diagnosis of Inflammatory Diseases of the Labyrinth [PDF]

Annals of Otology, Rhinology & Laryngology, 1917
n ...
openaire   +2 more sources

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Diseases and symptoms associated with changes in postural balance in diabetics: an integrating literature review

Revista CEFAC
Purpose: to verify the diseases and symptoms associated with changes in postural balance in middle-aged and elderly individuals with type 2 diabetes mellitus.
Eliza Mikaele Tavares da Silva, Bartolomeu Fagundes de Lima Filho, Érika Barioni Mantello, André Gustavo Pires de Sousa, José Diniz Júnior, Juliana Maria Gazzola   +5 more
doaj   +1 more source

Clinical features of benign paroxysmal positional vertigo Vertigem posicional paroxística benigna: caracterização clínica

Brazilian Journal of Otorhinolaryngology, 2009
Benign paroxysmal positioning vertigo (BPPV) is considered as the most common vestibular disease. AIM: to evaluate the age, gender, type and site of the lesion, association with other vestibular diseases, progression, and recurrence in these patients ...
Mariana Azevedo Caldas, Cristina Freitas Ganança, Fernando Freitas Ganança, Maurício Malavasi Ganança, Heloisa Helena Caovilla   +4 more
doaj   +1 more source

The Drawing Labyrinth

, 2018
Background This drawing event continues an ongoing research pursuit of the contemporary phenomenon of ‘performance drawing’ and combines it with ongoing research into the use of puppets in drawing practice.
Platz, William
core  

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Assessment of the effect of mesoglycan in the treatment of audiovestibular disorders of vascular origin

International Journal of Immunopathology and Pharmacology, 2018
It is a well-known fact that inner ear diseases are often caused by microcirculatory disorders, and the recent literature is oriented towards investigations into the relationship between the cardiovascular system and cochleovestibular illness with ...
Giampiero Neri, Vincenzo Marcelli, Luigi Califano,   +3 more
doaj   +1 more source

Maylis de Kerangal’s Réparer les vivants: a saving labyrinth

This article focuses on the modern image of the labyrinth-rhizome in Maylis de Kerangal’s novels. Basing on the analyses of Gilles Deleuze and Felix Guattari (introduction to Mille plateaux), we explain the characteristics of this strange labyrinth ...
Guillaume Rousseau
core   +1 more source