Results 71 to 80 of about 2,149,670 (310)

Unlocking the secrets of aging: Epigenetic reader BRD4 as the target to combatting aging-related diseases

Journal of Advanced Research
Background: Aging, a complex and profound journey, leads us through a labyrinth of physiological and pathological transformations, rendering us increasingly susceptible to aging-related diseases.
Jiaxing Sun, Yu Gui, Shenghua Zhou, Xi-Long Zheng   +3 more
doaj   +1 more source

3D didactic model and useful guide of the semicircular conducts Modelo didático 3D e guia útil dos canais semicirculares

Brazilian Journal of Otorhinolaryngology, 2011
Knowledge of the anatomy and physiology of the semicircular canals and their central pathways is essential for the diagnosis of vestibular pathology.
Ricardo D'Albora Rivas
doaj   +1 more source

Simon Bolivar's Medical Labyrinth: An Infectious Diseases Conundrum [PDF]

Clinical Infectious Diseases, 2011
According to history books, tuberculosis was responsible for the death of Simon Bolivar at the age of 47 years in 1830. The results of an autopsy performed by Alexandre Prospère Révérend, the French physician who cared for him during the terminal phase of his illness, have long been regarded as proof of the diagnosis. On careful reanalysis of Bolivar's
Paul G, Auwaerter, John, Dove, Philip A, Mackowiak   +2 more
openaire   +2 more sources

A "Labyrinth of Linkages" in Tolstoy's "Anna Karenina" [PDF]

, 2010
The renowned Russian writer Leo Tolstoy created a realistic masterpiece in Anna Karenina (1878). In the same work, moreover, he utilized allegory and symbol to an extent and at a level of sophistication unknown in his other works.
Gary L. Browning, Browning, Gary L., Browning, Gary.   +2 more
core   +1 more source

Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels

Advanced Science, EarlyView.
A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...
Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma   +17 more
wiley   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

The Axis of Progression of Disease

Cancer Informatics, 2014
Starting with genetic or environmental perturbations, disease progression can involve a linear sequence of changes within individual cells. More often, however, a labyrinth of branching consequences emanates from the initial events. How can one repair an
Alan M. Tartakoff, Di Wu
doaj   +1 more source

Axonal changes in experimental prion diseases recapitulate those following constriction of postganglionic branches of the superior cervical ganglion: a comparison 40 years later

Prion, 2019
The major neurological feature of prion diseases is a neuronal loss accomplished through either apoptosis or autophagy. In this review, I compared axonal alterations in prion diseases to those described 40 years earlier as a result of nerve ligation.
Paweł P. Liberski
doaj   +1 more source

Augustine Tower labyrinth

, 2018
St Augustine's Tower, Hackney. Creating and walking a cross-shaped 'stepping stone' temporary labyrinth on the footprint of a lost church.
Penfold, E., Overall, S.
core  

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source