Results 71 to 80 of about 19,094 (297)

Interleukin-10 in viral diseases and cancer: exiting the labyrinth?

Immunological Reviews, 2004
Summary:  Interleukin‐10 (IL‐10) is unique among cytokines, as it is considered both as a potent immunostimulatory and immunosuppressive factor. This complex biology has been particularly challenging when trying to define the useful or harmful role of IL‐10 in chronic viral diseases and cancer.
Giorgio Trinchieri, Alain P. Vicari
core   +3 more sources

Clinical Study of the Serous and Purulent Diseases of the Labyrinth [PDF]

The Journal of Nervous and Mental Disease, 1916
n ...
openaire   +2 more sources

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Avaliação e reabilitação vestibular no indivíduo idoso

Revista Brasileira de Geriatria e Gerontologia
Considerando a necessidade de propiciar melhora na qualidade de vida do idoso e a elevada incidência de queixas relacionadas aos transtornos de equilíbrio nessa faixa etária, este estudo teve como objetivo avaliar o equilíbrio estático e dinâmico de ...
Natália Daniela Rezende Mirallas, Marta Helena Souza De Conti, Alberto De Vitta, Ruy Laurenti, Sandra de Oliveira Saes   +4 more
doaj   +1 more source

PROGRESSIVE DEAFNESS, OTOSCLEROSIS AND DISEASES OF THE LABYRINTH

Archives of Otolaryngology - Head and Neck Surgery, 1931
In the past year Lange 1 has given the results of his study of the early pathologic changes in otosclerosis. The material used consisted of sixty-six temporal bones from forty-five patients. The site of the foci was noted as follows: oval window alone, twenty-two; both windows, seven, and round window alone, four.
J. K. M. DICKIE
core   +2 more sources

Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease

, 2021
The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of chorioretinal diseases, many of which are poorly understood. Recent advances in the field of single-cell RNA sequencing have yielded valuable insights into the
Emri, E., van Dijk, E. H. C., Brinks, J., Meijer, O. C., Kielbasa, S. M., Boon, C.J.F., Boon, C. J. F., Quax, P.H.A., Bergen, A.A., Bergen, A. A., Schlingemann, R.O., Schlingemann, R. O., Kielbasa, S.M., Quax, PHA, Boon, CJF, Quax, P. H. A., Dijk, E.H.C. van, Klaassen, I., Meijer, O.C., van Dijk, EHC   +19 more
core   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

3D didactic model and useful guide of the semicircular conducts Modelo didático 3D e guia útil dos canais semicirculares

Brazilian Journal of Otorhinolaryngology, 2011
Knowledge of the anatomy and physiology of the semicircular canals and their central pathways is essential for the diagnosis of vestibular pathology.
Ricardo D'Albora Rivas
doaj   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Axonal changes in experimental prion diseases recapitulate those following constriction of postganglionic branches of the superior cervical ganglion: a comparison 40 years later

Prion, 2019
The major neurological feature of prion diseases is a neuronal loss accomplished through either apoptosis or autophagy. In this review, I compared axonal alterations in prion diseases to those described 40 years earlier as a result of nerve ligation.
Paweł P. Liberski
doaj   +1 more source