Results 141 to 150 of about 9,217,738 (367)

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

Avaliação vestibular em mulheres com disfunção temporomandibular Vestibular evaluation in women with temporomandibular dysfunction

Revista CEFAC, 2007
OBJETIVO: avaliar o comportamento vestibular em pacientes com disfunção temporomandibular. MÉTODOS: avaliaram-se 27 pacientes do sexo feminino, na faixa etária de 30 a 53 anos, encaminhadas do Centro de Diagnóstico e Tratamento da Articulação ...
Bianca Simone Zeigelboim, Ari Leon Jurkiewicz, Jackeline Martins-Bassetto, Karlin Fabianne Klagenberg   +3 more
doaj   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Human malignant ovarian germ cell tumor cell lines derived from peritoneal cytology retrieving from circulating tumor cell system

Cancer Treatment and Research Communications
Background: Malignant ovarian germ cell tumor (MOGCT) is a rare neoplasm predominantly affecting adolescent and young adult females. Establishing personalized permanent tumor cell lines is crucial for understanding tumor behavior and optimizing precision
Jie Yang, Xinyue Zhang, Jie Tang, Xiaolei Fu, Qiong Wu, Hong Li, Rui Chen, Jiaxin Yang   +7 more
doaj   +1 more source

The Impact of Power Training on Balance and Visual Feedback Removal [PDF]

, 2019
Because power training has been known to augment stability, the purpose of this study was to assess whether the removal of visual input affects lower limb muscle power production in young women who are resistance trained to the same degree it affects the
Bouton, Juliana
core   +1 more source

Neutrophil Extracellular Traps Affect Human Inner Ear Vascular Permeability

International Journal of Molecular Sciences
The integrity of the blood–labyrinth barrier (BLB) is essential for inner ear homeostasis, regulating the ionic composition of endolymph and perilymph and preventing harmful substance entry.
Marijana Sekulic, Stavros Giaglis, Nina Chatelain, Daniel Bodmer, Vesna Petkovic   +4 more
semanticscholar   +1 more source

Estrogen Alleviates Sevoflurane‐Induced Neurotoxicity by Inhibiting ERα‐Tau Binding

Advanced Science, EarlyView.
Sevoflurane‐induced neurotoxicity exhibits sex differences, and estrogen can mitigate these effects; however, its protective action appears to be time‐window dependent, which may be related to the competitive binding of estrogen and Tau to ERα. Abstract Sevoflurane‐induced neurotoxicity is age‐dependent, but the role of sex differences is unclear ...
Feixiang Li, Bingqing Gong, Zichen Song, Nuo Yang, Yuming Liu, Jinqin Zhang, Dujuan Li, Yongyan Yang, Yonghao Yu   +8 more
wiley   +1 more source

Labyrinthopathies (Vestibulopathies) in Practice of a Therapeutist

Львівський клінічний вісник, 2013
Introduction. In 1861, Prosper Meniere for the first time proved that the cause of dizziness, nystagmus, and vertigo disorders may be the disease of the anterior part of labyrinth.
Kitsera Ol.Om., Kitsera Оl.Оl.
doaj   +1 more source

Diagnosis of latent forms of labyrinthine affections [PDF]

Features and significance of individual vestibular symptoms for the diagnosis of latent labyrinthitis and limited forms of labyrinthine affections offering considerable difficulties are discussed. Vestibular symptoms are indistinct.
Vaslilyeva, V. P.
core   +1 more source

Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation

Advanced Science, EarlyView.
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li, Maoxiang Xu, Boyu Cai, Xiangyu Li, Zhanping Liang, Xiaohuan Xia, Haitao Zhang, Zhiwen Zhang, Fei Tan, Jialin Charlie Zheng   +9 more
wiley   +1 more source