Results 71 to 80 of about 9,324,522 (375)
Advanced Science, EarlyView.Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye +7 more
wiley +1 more source
Recovery of Cochlear and Vestibular Function after Labyrinthine Haemorrhage
Acta Médica Portuguesa, 2014 Inner ear haemorrhage is a rare disorder with disabling symptoms. Prognosis is generally considered to be poor with essentially no chance of functional recovery. The most common aetiologies are related to blood dyscrasias, anticoagulant therapy or local
José Araújo-Martins +3 more
doaj +1 more source
Useful residual hearing despite radiological findings suggestive of anacusis [PDF]
, 1999 A severe malformation of the inner ear, often referred to as severe labyrinthine dysplasia or common cavity deformity, consists of an absent or dilated cochlear basal coil, wide communication with the vestibule and a tapered internal acoustic meatus and ...
Bamiou, DE, Mahoney, CO, Sirimanna, T
core +1 more source
Advanced Science, EarlyView.GeTe exhibits intrinsically high carrier concentrations that limit its thermoelectric performance. Herein, CuAgSe alloying synergistically tunes the band structure, induces band flattening and valence‐band convergence, promotes Cu‐ion delocalization, and generates multiscale hierarchical structures to suppress phonon transport.
Junhang Park +13 more
wiley +1 more source
Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery
Pharmaceutics, 2021 Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup of nanovesicles called exosomes has been driving the research field to a new regime for understanding cellular communication.
Rebekah Omarkhail Elliott, Mei He
doaj +1 more source
Derelict architecture: Aesthetics of an unaesthetic space [PDF]
, 2015 The main focus of this article is the question of the aesthetics of an unaesthetic ruined space.The author also pays particular attention to the ambivalence that exists in contemporary derelict architecture, referred to as ‘modern ruins’, and tries to ...
Nieszczerzewska, Małgorzata
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NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex
Advanced Science, EarlyView.The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang +8 more
wiley +1 more source
Prion, 2019 The major neurological feature of prion diseases is a neuronal loss accomplished through either apoptosis or autophagy. In this review, I compared axonal alterations in prion diseases to those described 40 years earlier as a result of nerve ligation.
P. Liberski
semanticscholar +1 more source
Advanced Science, EarlyView.Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu +5 more
wiley +1 more source
Progressive auditory neuropathy in patients with Leber's hereditary optic neuropathy [PDF]
, 2004 Objective: To investigate auditory neural involvement in patients with Leber's hereditary optic neuropathy (LHON).Methods: Auditory assessment was undertaken in two patients with LHON.
Ceranic, B, Luxon, LM
core +2 more sources