Results 51 to 60 of about 3,440 (255)

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Sub‐Unit‐Cell Logic Governs Transport in TPMS Architectures

Advanced Science, EarlyView.
ABSTRACT Next‐generation energy, thermal, and chemical systems require architectures capable of highly efficient transport across multiple length scales. Triply periodic minimal surfaces (TPMS), first conceptualized in 1865, offer inherently scalable geometries with exceptional transport potential, yet mechanistic links between topology and performance
Haozhang Zhong, Yipei He, Jiaxuan Wang, Chenyi Qian, Gerd E Schröder‐Turk, Raj Das, Junye Shi, Qi Tang, Zheda Ning, Wenjue Yi, Chuanwei Li, Jiangping Chen, Zeyao Chen, Binbin Yu, Jian LU, Jianfeng Gu, Ma Qian   +16 more
wiley   +1 more source

Relationships among tissues, biofluids, and otolith selenium concentrations in wild female burbot (Lota lota)

Integrated Environmental Assessment and Management, EarlyView., 2023
Abstract In the Lake Koocanusa‐Kootenai River system (Montana, USA and British Columbia, Canada), selenium (Se) contamination has become an international concern and is suspected to contribute to the observed burbot (Lota lota) population collapse. Due to our limited ability to sample burbot in Lake Koocanusa for monitoring studies, we used a reference
Stephanie D. Graves, Noëlie Molbert, David M. Janz, Lauren D. Hayhurst, Jessica E. Brandt, Lauren Timlick, Vince P. Palace   +6 more
wiley   +1 more source

Magneto‐X Effects in Magnetic Soft Materials and Their Applications

Advanced Science, EarlyView.
This review systematically explores magnetic soft materials (MSMs), a novel class of composites that transform under magnetic fields. It catalogs fundamental “Magneto‐X” effects, classifies materials by their matrix and magnetic fillers, and highlights transformative applications in soft robotics, biomedical devices, flexible electronics, etc. Finally,
Ziyin Xiang, Xiangling Xia, Benjamin Ducharne, Yujie Ye, Jie Shang, Run‐Wei Li   +5 more
wiley   +1 more source

The Shapes of Flux Domains in the Intermediate State of Type-I Superconductors

, 1997
In the intermediate state of a thin type-I superconductor magnetic flux penetrates in a disordered set of highly branched and fingered macroscopic domains.
A. B. Pippard, A. Bodmer, A. Bodmer, A. Cebers, A. Fortini, A. Hagberg, A. J. Dickstein, A. Kashuba, A. Kashuba, A. L. Fetter, A. O. Tsebers, A. T. Dorsey, Alan T. Dorsey, Ar. Abanov, C. A. Duran, C. B. Muratov, C. Flament, C. Kooy, D. A. Kessler, D. Andelman, D. J. E. Callaway, D. M. Petrich, D. P. Jackson, E. R. Andrew, F. Haenssler, F. Liu, G. Birkhoff, G. Lasher, H. Bokil, H. Frahm, I. V. Sharvin, J. A. Cape, J. C. Osborn, J. P. Hurault, J. Pearl, J. S. Nagumo, J. Toner, K. J. Lee, K. J. Lee, K. J. Stine, K. Maki, K. Y. C. Lee, K.-O. Ng, L. D. Landau, M. C. Cross, M. Seul, M. Seul, R. E. Goldstein, R. E. Goldstein, R. E. Goldstein, R. E. Rosensweig, R. FitzHugh, R. FitzHugh, R. N. Goren, R. P. Huebener, R. P. Huebener, R. V. Kohn, Raymond E. Goldstein, S. A. Langer, S. J. Chapman, T. E. Faber, W. Helfrich, W. W. Mullins   +62 more
core   +1 more source

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

Advanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou, Qingyuan Wu, Yang Wu, Runzhe Huang, Wei Li, Hanjie Niu, Hongtao Sun, Huiyu Liu   +7 more
wiley   +1 more source

Investigation Into the Dynamics of the Cupula in the Vestibular Organ of Adult Zebrafish Using Metabolic Glycoengineering

Angewandte Chemie, EarlyView.
The cupula is a membrane within the vestibular organ that senses rotatory accelerations of the head. Metabolic glycoengineering in combination with bioorthogonal labeling demonstrates that in adult zebrafish – being a model for the human inner ear – this membrane is constantly renewed.
Hans Scherer, Andrea Jüngst, Verena F. Schöwe, Anne‐Katrin Gronewald, Valentin Wittmann   +4 more
wiley   +2 more sources

Novel Experimentally Observed Phenomena in Soft Matter

, 2013
Soft materials such as colloidal suspensions, polymer solutions and liquid crystals are constituted by mesoscopic entities held together by weak forces. Their mechanical moduli are several orders of magnitude lower than those of atomic solids.
Bandyopadhyay, Ranjini
core   +1 more source

Multiparametric Bioresorbable Sensor for Doxorubicin Detection via Molecularly Imprinted Synthetic Receptors

Advanced Science, EarlyView.
A biodegradable molecularly imprinted polymer porous silica sensor enables dual optical readout of doxorubicin via fluorescence and effective optical thickness shifts. The combined transduction mechanisms provide enhanced reliability and quantitative accuracy over clinically relevant concentrations, representing a step toward transient implantable ...
Martina Corsi, Tiziano Di Giulio, Eleonora Vandini, Muhammad Ibrar Asif, Eleonora Daini, Antonietta Vilella, Giuseppina Leo, Alessandra Ottani, Cosimino Malitesta, Daniela Giuliani, Elisabetta Mazzotta, Giuseppe Barillaro   +11 more
wiley   +1 more source