Results 31 to 40 of about 93,344 (216)

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, EarlyView.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source

Utiliser les réseaux trophiques comme indicateur fonctionnel du changement global

Sciences, Eaux & Territoires
La structure des réseaux trophiques, c’est-à-dire « qui mange qui », est un élément central pour comprendre le fonctionnement des plans d’eau et anticiper les effets des changements globaux.
Arnaud SENTIS, Camille LECLERC, Najwa SHARAF, Rosalie BRUEL, Nathalie REYNAUD, Victor FROSSARD   +5 more
doaj   +1 more source

Immobilization of urease in alginate, paraffin and lac [PDF]

Journal of the Serbian Chemical Society, 2010
The enzyme urease (EC.3.5.1.5) from jack bean meal was immobilized by various techniques, such as entrapment in calcium alginate gel spheres in aqueous suspension; lac impregnated muslin cloth as dry films and by embedding in paraffin wax impregnated ...
ANITA BAHADUR, NEELAM MISHRA, KESPI PITHAWALA   +2 more
doaj  

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Panorama des réseaux de surveillance des plans d’eau en France

Sciences, Eaux & Territoires
Les réseaux de surveillance des lacs français, qu’ils soient réglementaires (DCE), scientifiques (OLA, Lacs Sentinelles), opérationnels ou thématiques (suivi d’opérations de restaurations), fournissent des données essentielles pour évaluer l’état des ...
Thierry TORMOS, Nathalie REYNAUD
doaj   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Les évolutions thermiques des lacs français face au changement climatique : surveillance et prédiction

Sciences, Eaux & Territoires
La température constitue un facteur déterminant du fonctionnement, de la dynamique chimique et de l’équilibre écologique des lacs. Or, les observations confirment une tendance généralisée à l’augmentation des températures de surface des plans d’eau sous
Rosalie BRUEL, Najwa SHARAF, Olivia DESGUE-ITIER, Jordi PRATS, Nathalie REYNAUD, Tiphaine PEROUX, Thierry TORMOS, Pierre-Alain DANIS, Jean-Philippe JENNY   +8 more
doaj   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Potential Cost Savings of Off-Site Regional Anesthesia for Minor Orthopedic Surgical Procedures

Медицина болю, 2016
This study is limited by the fact that each hospital has different costs for staffing as well as ambiguous billing patterns that make it difficult to correctly appreciate the value of perioperative staffing and costs for the hospital, insurance company ...
J. Berger, D. F. Gutierrez, A. Shbeeb, L. Ngai, Z. Meliksetyan, V. Zelman   +5 more
doaj  

Un sac, des gants, un croc de jardin : le déterrage précoce, une technique douce contre l'envahissement des rivières par les renouées asiatiques

Sciences, Eaux & Territoires, 2019
En période de crues, l'érosion des berges envahies par les renouées asiatiques contribue à la dissémination des plantes le long des rivières. En effet, des fragments végétatifs sont arrachés, transportés par l'eau puis déposés un peu plus en aval, où ils
L. BARTHOD, M. BOYER
doaj   +1 more source