Results 41 to 50 of about 148,747 (310)
Structure, 1996 Crystal and cocrystal structures of the LacI and PurR repressors reveal a novel use of hinge alpha helices which bind in the minor groove of the operator and mediate transmission of the allosteric signals that modulate DNA-binding activity.
openaire +2 more sources
Le boom des motoculteurs au Lac Alaotra à Madagascar [PDF]
, 2009 Depuis le début des années 2000 , les motoculteurs rencontrent un succès important dans la région du Lac Alaotra au nord de Madagascar. Au delà d'un investissement quasi égal à celui de l'attelage traditionnel, c'est son caractère multifonctionnel qui ...
Dabat, Marie-Hélène +7 more
core
Advanced Science, EarlyView.Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen +8 more
wiley +1 more source
Angewandte Chemie, EarlyView.A coumarin‐based dual‐emission fluorophore was designed to visualize the maturation of protein liquid droplets. Upon covalent conjugation to droplet‐forming proteins, ratiometric fluorescence imaging allowed real time monitoring of droplet maturation. This probe is applicable to the analysis of droplet formation and maturation mechanisms, as well as to
Tomoya Yamamoto +6 more
wiley +2 more sources
Centralisation et diffusion des données sur les lacs en France (DataECLA)
Sciences, Eaux & TerritoiresLa plateforme DataECLA (Données sur les écosystèmes lacustres) a été développée par le Pôle R&D ECLA (Pôle Recherche et Développement Écosystèmes lacustres) pour répondre aux enjeux croissants de centralisation, d’accessibilité et de valorisation des ...
Thierry TORMOS, Nathalie REYNAUD
doaj +1 more source
Advanced Science, EarlyView.Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo +14 more
wiley +1 more source
Le retour du lavaret : une action d'ingénierie écologique réussie à l'échelle d'un lac (Le Bourget)
Sciences, Eaux & Territoires, 2015 Les grands lacs alpins fournissent de nombreux services écosystémiques: supports, approvisionnement, régulation, culturels et récréatifs. Ils sont soumis à des pressions multiples, globales et locales, issues de leur bassin versant (flux de nutriments ...
J. GUILLARD +3 more
doaj +1 more source
, 2017 After a growth slowdown that lasted six years (including a contraction of 1.3 percent last year), the Latin American and Caribbean (LAC) region is finally expected to resume positive growth in 2017, with market analysts forecasting real GDP growth of 1.2
Friedheim, Diego +7 more
core +1 more source
Advanced Science, EarlyView.Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan +7 more
wiley +1 more source
« La petite mer d’Enghien » : un site pour une villégiature parisienne
In Situ, 2014 At the same time Lake of Elvira, Lake Maggiore, Geneva Lake, beloved ground of the author of Émile, one of the most attractive countries of the world, the real miniature of the big Swiss lakes, the small sea...
Sophie Cueille
doaj +1 more source