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Genetic mapping of a new promoter for the lac operon
Journal of Molecular Biology, 1975Abstract A mutation (or group of mutations) necessary for the synthesis of increased quantities of lac mRNA has been localized within the structural gene for the lac repressor ( lacI ). This mutation is probably a new cyclic AMP-binding protein-dependent promoter within the I gene.
Paula De Lucia-Curtin, Jeremy Bruenn
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The Mechanism of Activation of the Lac Operon
1972The lac operon consists of a cluster of genes found on the single chromosome of the bacterium Escherichia coli. Starting from one side the cluster contains a promoter, an operator, the structural genes for β-galactosidase, permease and thiogalactoside transacetylase.1 Such a grouping of regulating and structural genes is termed an operon. In 1961 Jacob
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Characteristics of tight binding repressors of the lac operon
Journal of Molecular Biology, 1981Abstract A number of tight binding lac repressor mutants (Itb) have been analyzed. The mutant repressors could be shown to have altered DNA binding properties, which can include an increased affinity for operator DNA, an increased affinity for non-specific DNA, or a decreased affinity for non-specific DNA.
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Dynamics and bistability in a reduced model of the lac operon
Chaos: An Interdisciplinary Journal of Nonlinear Science, 2004It is known that the lac operon regulatory pathway is capable of showing bistable behavior. This is an important complex feature, arising from the nonlinearity of the involved mechanisms, which is essential to understand the dynamic behavior of this molecular regulatory system.
Daisuke Horike +3 more
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Cost-Benefit Tradeoffs in Engineered lac Operons
Science, 2012Accounting for Lac When Escherichia coli expresses the lac operon, it needs to balance the potential increase in growth rate conferred through having the encoded proteins (which help it to take up and metabolize lactose) with the potential ...
Tanja Kortemme, Matt Eames
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1996
In 1961, Jacob and Monod proposed the operon model of gene expression and its negative control primarily from the experimental results obtained by these authors and their colleagues studying the induced synthesis of proteins involved in the utilization of sugar lactose and development of bacteriophage X from a prophage state in Escherichia coli.
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In 1961, Jacob and Monod proposed the operon model of gene expression and its negative control primarily from the experimental results obtained by these authors and their colleagues studying the induced synthesis of proteins involved in the utilization of sugar lactose and development of bacteriophage X from a prophage state in Escherichia coli.
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Isolation and characterization of frameshift mutations in the lac operon
Journal of Molecular Biology, 1970Abstract A set of lac − mutations has been isolated in cells of Escherichia coli after mutagenesis with ICR-191D, an acridine half-mustard known to cause frameshifts in bacteria. The mutations in the β-galactosidase gene ( z ) were studied and shown to have properties consistent with their assignment to the frameshift class: they are revertible ...
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The catabolite repression gene of the Lac operon in Escherichia coli
Journal of Molecular Biology, 1967A new gene, CR, has been shown to participate in the control of transcription of the lac operon. A mutation in the CR gene leads to insensitivity to catabolite repression of the lac operon. No other changes could be found to result from the mutation. The CR gene appears to map genetically distant from the lac genes and near the tryptophan locus.
William F. Loomis, Boris Magasanik
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