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The Controversial Role of Human Gut Lachnospiraceae [PDF]

Microorganisms, 2020
The complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal lumen from birth and increasing, in terms of species richness and their ...
Mirco Vacca, Giuseppe Celano, Francesco Maria Calabrese   +2 more
exaly   +8 more sources

Members of Lachnospiraceae produce valerate and caproate in response to short-chain fatty acids [PDF]

Microbiome
Background The human gut microbiota ferments carbohydrates to produce metabolites that mediate beneficial community functions. While the production of the short-chain fatty acids (SCFAs) acetate, propionate, and butyrate is well characterized, how ...
Bradley G. Fitzgerald, Manitabhai Govind, Isaac J. Firth, Loudon Herold, Julia Froment, Sarah J. Vancuren, Emma Allen-Vercoe, Matthew S. Kimber, Matthew T. Sorbara   +8 more
doaj   +6 more sources

Untangling the Genetic Basis of Fibrolytic Specialization by Lachnospiraceae and Ruminococcaceae in Diverse Gut Communities [PDF]

Diversity, 2013
The Lachnospiraceae and Ruminococcaceae are two of the most abundant families from the order Clostridiales found in the mammalian gut environment, and have been associated with the maintenance of gut health. While they are both diverse groups, they share
Amy S Biddle, Lucy C Stewart, Jeffrey Blanchard   +2 more
exaly   +7 more sources

A more efficient CRISPR-Cas12a variant derived from Lachnospiraceae bacterium MA2020 [PDF]

Molecular Therapy: Nucleic Acids, 2021
CRISPR effector proteins introduce double-stranded breaks into the mammalian genome, facilitating gene editing by non-homologous end-joining or homology-directed repair.
Mai H. Tran, Hajeung Park, Christopher L. Nobles, Pabalu Karunadharma, Li Pan, Guocai Zhong, Haimin Wang, Wenhui He, Tianling Ou, Gogce Crynen, Kelly Sheptack, Ian Stiskin, Huihui Mou, Michael Farzan   +13 more
doaj   +4 more sources

Metabolite profiling of human‐originated Lachnospiraceae at the strain level

iMeta, 2022
The human gastrointestinal (GI) tract harbors diverse microbes, and the family Lachnospiraceae is one of the most abundant and widely occurring bacterial groups in the human GI tract.
Shuang-Jiang Liu
exaly   +4 more sources

Lachnospiraceae bacterium alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway [PDF]

Gut Microbes
Alcohol-associated liver disease (ALD) is a prevalent global health issue primarily caused by excessive alcohol consumption. Recent studies have highlighted the gut-liver axis’s protective role against ALD, mainly through gut microbiota.
Hejiao Zhang, Qiang Hu, Yong Zhang, Lei Yang, Shanfei Tian, Xinru Zhang, Haiyuan Shen, Hang Shu, Linxi Xie, Dongqing Wu, Liangliang Zhou, Xiaoli Wei, Chen Cheng, Jiali Jiang, Hua Wang, Cailiang Shen, Derun Kong, Long Xu   +17 more
doaj   +3 more sources

The Lachnospiraceae-butyric acid axis and its role in glucocorticoid-associated osteonecrosis [PDF]

Journal of Translational Medicine
Glucocorticoids (GCs) are key inducers of osteonecrosis, yet not all patients treated with GCs develop glucocorticoid-associated osteonecrosis (GAON). The factors mediating this relationship are unclear.
Mingbin Guo, Shuai He, Wei Song, Jianbin Mai, Xinwei Yuan, Yixuan Huang, Hongzhong Xi, Guangquan Sun, Yugen Chen, Bin Du, Xin Liu   +10 more
doaj   +4 more sources

Changes in Probiotic Lachnospiraceae Genera Across Different Stages of COVID-19: A Meta-Analysis of 16S rRNA Microbial Data [PDF]

Microorganisms
The gut microbiome has emerged as a potential modulator of COVID-19 severity, and there is particular interest in the Lachnospiraceae family due to its role in maintaining gut homeostasis.
Clarissa Reginato Taufer, Juliana da Silva, Pabulo Henrique Rampelotto   +2 more
doaj   +2 more sources

Replacing saturated fatty acids with polyunsaturated fatty acids increases the abundance of Lachnospiraceae and is associated with reduced total cholesterol levels—a randomized controlled trial in healthy individuals [PDF]

Lipids in Health and Disease, 2022
Background Improving dietary fat quality strongly affects serum cholesterol levels and hence the risk of cardiovascular diseases (CVDs). Recent studies have identified dietary fat as a potential modulator of the gut microbiota, a central regulator of ...
Vibeke H. Telle-Hansen, Line Gaundal, Nasser Bastani, Ida Rud, Marte G. Byfuglien, Terje Gjøvaag, Kjetil Retterstøl, Kirsten B. Holven, Stine M. Ulven, Mari C. W. Myhrstad   +9 more
doaj   +2 more sources

Tirzepatide, a dual GLP-1 and GIP receptor agonist, promotes bone loss in obese mice via gut microbial-related metabolites [PDF]

Journal of Orthopaedic Translation
Background: As a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist, Tirzepatide (TZP) is a recently approved medication for treating type 2 diabetes mellitus (T2DM) and obesity; however ...
Ning Chen, Mengdan Zhang, Baohong Shi, Xiumei Luo, Rui Huang, Zhengqiong Luo, Junliang He, Shengye Xue, Na Li, Zemin Ling, Hao Guo, Ren Xu, Yuejun Liu   +12 more
doaj   +2 more sources