Urease in acetogenic Lachnospiraceae drives urea carbon salvage in SCFA pools
Gut MicrobesThe gut microbiota produces short-chain fatty acids (SCFA) and acidifies the proximal colon which inhibits enteric pathogens. However, for many microbiota constituents, how they themselves resist these stresses is unknown.
Isaac J. Firth +9 more
doaj +4 more sources
Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury
Cell ReportsSummary: While fecal microbiota transplantation (FMT) shows promise in treating human diseases, oral capsule FMT is more accepted and accessible to patients.
Sen-Yung Hsieh
exaly +5 more sources
Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria
Life, 2023 (1) Background: Chronic spontaneous urticaria (CSU) has been linked to the dysbiosis of the gut microbiota. Furthermore, various studies have highlighted the anti-inflammatory properties of short-chain fatty acids (SCFAs), whose production is primarily ...
Diana Ćesić +10 more
doaj +3 more sources
Intestinal Lachnospiraceae bacterium-derived propionate inhibits the progression of clear cell renal cell carcinoma [PDF]
Cell Reports MedicineSummary: Gut microbiota has been reported to be associated with the development of various diseases; however, its interaction with clear cell renal cell carcinoma (ccRCC) remains unknown.
Jun-Yao Xu +8 more
doaj +3 more sources
Prematurely delivering mothers show reductions of lachnospiraceae in their gut microbiomes
BMC Microbiology, 2023 Background Preterm birth is the leading cause of perinatal morbidity and mortality. Despite evidence shows that imbalances in the maternal microbiome associates to the risk of preterm birth, the mechanisms underlying the association between a perturbed ...
Ru Yang +7 more
doaj +3 more sources
Infant early gut colonization by Lachnospiraceae: high frequency of Ruminococcus gnavus [PDF]
Frontiers in Pediatrics, 2016 Lachnospiraceae is a bacterial family usually isolated from human and mammalian intestinal microbiota. However, its presence and role in the infant microbiota is not fully elucidated.
Valeria eSagheddu +4 more
doaj +4 more sources
Lachnospiraceae are emerging industrial biocatalysts and biotherapeutics
Frontiers in Bioengineering and BiotechnologyThe Lachnospiraceae is a family of anaerobic bacteria in the class Clostridia with potential to advance the bio-economy and intestinal therapeutics.
Tom Zaplana +2 more
doaj +3 more sources
A Phylogenomic View of Ecological Specialization in the Lachnospiraceae, a Family of Digestive Tract-Associated Bacteria [PDF]
Genome Biology and Evolution, 2014 Several bacterial families are known to be highly abundant within the human microbiome, but their ecological roles and evolutionary histories have yet to be investigated in depth. One such family, Lachnospiraceae (phylum Firmicutes, class Clostridia) is abundant in the digestive tracts of many mammals and relatively rare elsewhere.
Conor J Meehan, Robert G Beiko
exaly +7 more sources
Prevention and cure of murine C. difficile infection by a Lachnospiraceae strain
Gut MicrobesWe sought to better understand how intestinal microbiota confer protection against Clostridioides difficile (C. difficile) infection (CDI). We utilized gnotobiotic altered Schaedler flora (ASF) mice, which lack the abnormalities of germfree (GF) mice as ...
Juan Noriega Tejada +8 more
doaj +5 more sources
Aminopeptidase O Protein Mediates the association between Lachnospiraceae and Appendicular Lean Mass [PDF]
Frontiers in Microbiology, 2023 Abstract Objective: Investigating the causal relationship between Lachnospiraceae and Appendicular lean mass (ALM) and identifying and quantifying the role of Aminopeptidase O Protein (AOPEP) as a potential mediator. Methods: The summary statistics data of gut microbiota composition from the largest available genome-wide association study meta ...
Bingjun Gao +9 more
openalex +4 more sources