Results 141 to 150 of about 7,921 (224)

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, Volume 67, Issue 10, Page 5514-5530, October 2026.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Real‐world use of Cenobamate in pediatric drug‐resistant epilepsy: A European multicenter retrospective study

Epilepsia Open, Volume 11, Issue 5, Page 1863-1870, October 2026.
Abstract Pediatric drug‐resistant epilepsy (DRE) remains a significant clinical challenge, with few effective pharmacological options. This European multicenter retrospective study assessed the real‐world efficacy, tolerability, and retention of off‐label cenobamate (CNB) in 108 children and adolescents with DRE (median age: 13.83 years, range 3.9–19.8)
Konstantin L. Makridis, Thomas Bast, Stéphane Auvin, Pavel Krsek, Matyas Ebel, Eva Breuer, Mira Beckhaus, Matúš Bašovský, Pavlína Danhofer, Ondřej Horák, Alessandro Orsini, Gonzalo Alonso Ramos Rivera, Hana Medřická, Steffen Syrbe, Angela M. Kaindl   +14 more
wiley   +1 more source

Bridging computational and clinical strategies for presurgical identification of epileptogenic networks

Epilepsia Open, Volume 11, Issue 5, Page 1525-1540, October 2026.
Abstract Objective About one third of epilepsy patients are drug‐resistant. Resective epilepsy surgery remains a key treatment option but depends critically on accurate identification of the seizure onset zone (SOZ), which is still guided mainly by subjective visual inspection of electrophysiological signals.
Tena Dubcek, Debora Ledergerber, Kristina Koenig, Adham Elshahabi, Rafael Polania, Lukas Imbach   +5 more
wiley   +1 more source

Aphasic status epilepticus due to Epstein–Barr virus meningoencephalitis

Epileptic Disorders, Volume 28, Issue 5, Page 1709-1712, October 2026.
Gemma Bassani, Tobias Moser, Lukas Machegger, Fabio Rossini, Georg Pilz, Eugen Trinka, Giorgi Kuchukhidze   +6 more
wiley   +1 more source

Astrocyte subtype‐specific alterations in the dentate gyrus of individuals with mesial temporal lobe epilepsy

Epilepsia Open, Volume 11, Issue 5, Page 1651-1667, October 2026.
Abstract Objective Epilepsy affects approximately 50 million people worldwide and, although primarily attributed to neuronal dysfunction, increasing evidence highlights a critical role of glial cells, particularly astrocytes, in the pathophysiological mechanisms.
Chiara Lötzsch, Jakob Johann Schmidt, Daniel Delev, Roland Coras, Ingmar Blümcke, Ruth Beckervordersandforth   +5 more
wiley   +1 more source

Membrane-Dependent Adsorption of Lacosamide in CRRT: Implications for Drug Dosing in Critically Ill Renal Patients. [PDF]

Med Sci Monit
Nosek K, Samiec M, Ziółkowski H, Maksymowicz R, Matuszewski W, Onichimowski D, Markowska-Buńka P, Czaja K.   +7 more
europepmc   +1 more source

Salience network hub dysfunction is associated with cognitive impairment in self‐limited epilepsy with centrotemporal spikes: An OPM‐MEG study

Epilepsia Open, Volume 11, Issue 5, Page 1706-1717, October 2026.
Abstract Objective Self‐limited epilepsy with centrotemporal spikes (SeLECTS), although characterized by well‐controlled seizures, is frequently associated with persistent cognitive deficits in affected children. This study aimed to investigate whether hub dysfunction of the salience network (SN) is associated with cognitive impairment in SeLECTS ...
Chen Yang, Guangsheng Wu, Nan An, Tiejia Jiang, Yilong Wang, Wenbin Zhao, Wangyang Cao, Xiaofang Wang, Haiteng Jiang, Zhefeng Yuan   +9 more
wiley   +1 more source

New-Generation Antiseizure Medications: Who Takes the Lead in the Real World? [PDF]

Epilepsy Curr
Taraschenko O.
europepmc   +1 more source

Neuroimaging of the ictal–interictal continuum: Where do we stand? A systematic review and meta‐analysis of current evidence

Epilepsia Open, Volume 11, Issue 5, Page 1426-1436, October 2026.
Abstract Objective Patterns within the ictal–interictal continuum (IIC) are frequently encountered in critically ill patients undergoing continuous electroencephalographic studies and may reflect ongoing ictal activity or secondary brain injury. Peri‐ictal neuroimaging abnormalities (PNA) have been described in association with status epilepticus (SE),
Panagiota‐Eleni Tsalouchidou, Kateriine Orav, Tiago Lerda‐Casaccia, Leona Möller, Georgios Tsivgoulis, Anastasios Bonakis, Lukas Machegger, Giorgi Kuchukhidze, Susanne Knake, Eugen Trinka, Pilar Bosque‐Varela   +10 more
wiley   +1 more source

Economic burden and cost determinants of epilepsy in Georgia: A longitudinal cost‐of‐illness study

Epilepsia Open, Volume 11, Issue 5, Page 1786-1800, October 2026.
Abstract Objective To assess the economic burden, cost components, and individual‐level determinants of outpatient epilepsy care in adults in Georgia. Methods This longitudinal study of epilepsy‐related costs in adults with active epilepsy attending a tertiary epilepsy centre in Tbilisi collected clinical and sociodemographic data over 6 months. Direct
Sofia Kasradze, Tamar Jishkariani, Eka Burkadze, Ketevan Mamasakhlisi, Marika Megrelishvili, Josemir W. Sander   +5 more
wiley   +1 more source