Results 91 to 100 of about 980,886 (403)

Classification accuracy of different pork quality evaluation methods in assessment of meat with lowered drip loss

Ciência Rural, 2021
: This study compared the diagnostic value of pork quality evaluation methods using different pH threshold values and time-points with muscle metabolites concentration threshold values measured 45 min.
Krystian Tarczyński, Andrzej Zybert, Halina Sieczkowska, Elżbieta Krzęcio-Nieczyporuk, Katarzyna Antosik   +4 more
doaj   +1 more source

Neuroendocrinology of Lactation

Journal of Investigative Dermatology, 1974
Although other hormones influence the quantity of milk secretion, prolactin and adrenal corticosteroids are essential for initiating and maintaining lactation. During pregnancy high levels of estrogen and progesterone inhibit lactation, and elevation of prolactin and ACTH-adrenal corticosteroid levels result in the initiation of lactation at the end of
openaire   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Surface-Enhanced Raman Scattering Active Gold Nanoparticles with Enzyme-Mimicking Activities for Measuring Glucose and Lactate in Living Tissues.

ACS Nano, 2017
Gold nanoparticles (AuNPs) with simultaneous plasmonic and biocatalytic properties provide a promising approach to developing versatile bioassays. However, the combination of AuNPs' intrinsic enzyme-mimicking properties with their surface-enhanced Raman ...
Yihui Hu, Hanjun Cheng, Xiaozhi Zhao, Jiangjiexing Wu, Faheem Muhammad, Shichao Lin, Jian He, Liqi Zhou, Chengping Zhang, Yu Deng, Peng Wang, Zhengyang Zhou, S. Nie, Hui Wei   +13 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Estudo piloto sobre a eficácia do losartan no tratamento do fenômeno de Raynaud (FRy) e correlação com alterações na microcirculação em pacientes com esclerose sistêmica (ES) Pilot study on losartan efficacy in the treatment of Raynaud's phenomenon (RP) and correlation with microcirculation alterations in patients with systemic sclerosis (SSc)

Revista Brasileira de Reumatologia, 2005
OBJETIVOS: Avaliar a eficácia do losartan no tratamento do fenômeno de Raynaud (FRy) em pacientes com FRy secundário à esclerose sistêmica (ES). Avaliamos também as anormalidades bioquímicas da microcirculação, através de dosagem da lacticemia de polpa ...
Cristiane Kayser, Marla Francisca dos Santos, Luís Eduardo C. Andrade   +2 more
doaj   +1 more source

Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?

Journal of Clinical Medicine, 2020
Accumulating evidence from animal and human studies supports the notion that physical exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative diseases (e.g., dementia). However, the underlying neurobiological mechanisms
P. Müller, Yves Duderstadt, V. Lessmann, N. Müller   +3 more
semanticscholar   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Septic shock in the ER: diagnostic and management challenges

Open Access Emergency Medicine, 2019
Panita Worapratya, Prasit WuthisuthimethaweeDepartment of Emergency Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, ThailandAbstract: Sepsis is a common presentation in the emergency department and a common cause of ...
Worapratya P, Wuthisuthimethawee P
doaj  

Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis

Frontiers in Neuroscience, 2019
Regulation of metabolism is complex and involves enzymes and membrane transporters, which form networks to support energy dynamics. Lactate, as a metabolic intermediate from glucose or glycogen breakdown, appears to play a major role as additional ...
Joachim W. Deitmer, Shefeeq M. Theparambil, Ivan Ruminot, Sina I. Noor, Holger M. Becker   +4 more
doaj   +1 more source