Results 191 to 200 of about 60,229 (277)

Elevated lactate levels and impaired lactate clearance during extracorporeal life support (ECLS) are associated with poor outcome in cardiac surgery patients. [PDF]

PLoS One, 2022
Rissel R, Koelm S, Schepers M, Dohle DS, Albers J, Oezkur M, Kriege M, Bodenstein M.   +7 more
europepmc   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

Inside‐Outside ROS Therapeutic Strategy Based on Piezoelectric Nano‐Urchin for Drug‐Resistant Bacteria Biofilm Infections

Advanced Science, EarlyView.
The contribution of this study lies not only in enabling effective treatment of drug‐resistant biofilm infections, but also in establishing a transferable therapeutic paradigm: Ultrasound‐triggered mechanical forces synergistically enhance piezoelectric polarization and nanozyme activity, driving functional ROS generation inside and outside biofilms ...
Xinjian Guo, Jin Yang, Mengjie An, Bingjie Lin, Tao Liu, Limin Zhang   +5 more
wiley   +1 more source

Evaluating the role of high-dose intravenous thiamine supplementation for lactate clearance in patients with cirrhosis and sepsis.

Int J Crit Illn Inj Sci
Ali R, Yazdi A, Collins K, Guffey D, Wu TD, Kessinger R, Omranian A, Vallabh M.   +7 more
europepmc   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Prognostic value of lactate clearance, fluid balance, and APACHE II score in patients with cardiogenic shock receiving extracorporeal membrane oxygenation. [PDF]

Front Cardiovasc Med
Zhang QF, Zhang SL, Li G, Guo M, Qi XX, Xing XH, Wang Z.   +6 more
europepmc   +1 more source

Serum lactate and lactate clearance as early predictors of mortality in preterm neonates

Pediatrics & Neonatology
Vinay Kulkarni, Shiv Sajan Saini, Venkataseshan Sundaram, Kanya Mukhopadhay, Sourabh Dutta, Praveen Kumar   +5 more
openaire   +3 more sources

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Lactate Clearance of the Adsorber Cytosorb^® in Critically Ill Patients: A Post-Hoc Analysis of the Cyto-SOLVE Trial. [PDF]

Biomedicines
Wustrow V, Gräfe C, Graf H, Scheiermann P, Paal M, Vogeser M, Liebchen U, Scharf C.   +7 more
europepmc   +1 more source