Results 151 to 160 of about 344,963 (356)
Advanced Science, EarlyView.This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao +4 more
wiley +1 more source
Advanced Science, EarlyView.A structurally and functionally dual bionic bone adhesive is engineered through an organic–inorganic cohesion strategy, which significantly reinforces the adhesive's bone tissue adhesion as well as osteogenic activity. In a pioneering rabbit radius comminuted fracture model, the bone adhesive exhibits exceptional capability in immobilizing bone ...
Junyao Cheng +13 more
wiley +1 more source
Advanced Science, EarlyView.NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu +14 more
wiley +1 more source
LACTATE DEHYDROGENASE AS A CYTOPLASMIC MARKER IN BRAIN [PDF]
, 1963 MK JOHNSON, VP Whittaker
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Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance
Advanced Science, EarlyView.Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai +5 more
wiley +1 more source
An Automated Colorimetric (Tetrazolium Salt) Assay for Serum Lactate Dehydrogenase [PDF]
, 1966 Rodney D Capps +3 more
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Advanced Science, EarlyView.This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen +12 more
wiley +1 more source
Function of the lactate dehydrogenase B gene in mouse erythrocytes: evidence for control by a regulatory gene. [PDF]
, 1968 T.B. Shows, F.H. Ruddle
openalex +1 more source