Results 161 to 170 of about 785,757 (422)

Effects of Hyperbaric Hypoxia on Some Enzyme Systems in the Mammalian Liver [PDF]

open access: yes, 1978
The metabolic effects of hypobaric hypoxic stress on the mammalian liver were studied. The lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH) activity of mouse liver homogenates were measured after exposure to an equivalent altitude of 36,000 ...
Baeyens, Dennis A., Meier, M. J.
core   +2 more sources

Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis

open access: yesAmerican Journal of Emergency Medicine, 2020
B. Henry   +6 more
semanticscholar   +1 more source

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

open access: yesAdvanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang   +11 more
wiley   +1 more source

The role of activity indicators of redox enzymes in evaluation of cornea and conjunctiva condition in experimental hypothyroidism

open access: yesJournal of Ophthalmology, 2016
Introduction. Thyroid diseases rank the second place after diabetes mellitus by disease incidence. In recent years, a large number of hypothyroidism studies have showed structural and functional abnormalities in eye tissues. Purpose.
G.I. Drozhzhina, M.I. Pavlovsky
doaj   +1 more source

Usefullness of Lactate Dehydrogenase and Lactate Dehydrogenase Isoenzymes for Diagnosis of Acute Myocardial Infarction

open access: yesSurvey of Anesthesiology, 1988
The usefulness of lactate dehydrogenase (LD) and LD isoenzymes in the diagnosis of acute myocardial infarction (AMI) is controversial. The present study reviewed 507 consecutive patients in whom creatine kinase, creatine kinase isoenzymes, LD and LD isoenzymes were ordered over a 1-month period. Of these, 249 had an insufficient number of serial enzyme
Harvey Kaufman   +7 more
openaire   +4 more sources

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang   +4 more
wiley   +1 more source

Utilization of real‐world data in assessing treatment effectiveness for diffuse large B‐cell lymphoma

open access: yesAmerican Journal of Hematology, Volume 98, Issue 1, Page 180-192, January 2023., 2023
Abstract Direct comparisons of the effectiveness of the numerous novel therapies in the diffuse large B‐cell lymphoma (DLBCL) treatment landscape in a range of head‐to‐head randomized phase 3 trials would be time‐consuming and costly. Comparative effectiveness studies using real‐world data (RWD) represent a complementary approach.
Grzegorz Nowakowski   +4 more
wiley   +1 more source

Identification of Prognostic Biomarkers for Stage III Non-Small Cell Lung Carcinoma in Female Nonsmokers Using Machine Learning [PDF]

open access: yesarXiv
Lung cancer remains a leading cause of cancer-related deaths globally, with non-small cell lung cancer (NSCLC) being the most common subtype. This study aimed to identify key biomarkers associated with stage III NSCLC in non-smoking females using gene expression profiling from the GDS3837 dataset.
arxiv  

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