Results 221 to 230 of about 231,763 (293)

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Prediction of Periodontal Disease Progression During Supportive Periodontal Therapy Using an Oral Fluid Lactate Dehydrogenase Activity-Based Test Strip. [PDF]

J Clin Med
Yamamoto T, Sato S, Kamata Y, Hirata T, Nanashima K, Irie K, Komaki M.   +6 more
europepmc   +1 more source

Lactate dehydrogenase

, 2019
openaire   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Correlation between Interleukin-6, C-reactive protein, and lactate dehydrogenase levels and macrolide-resistant severe mycoplasma pneumoniae infection in children. [PDF]

BMC Infect Dis
Zhang M, Liu D, Song Y, Zhao J.
europepmc   +1 more source

Enzyme Sequence and Its Relationship to Hyperbaric Stability of Artificial and Natural Fish Lactate Dehydrogenases

, 2008
Amanda A. Brindley, Richard W. Pickersgill, Julian C. Partridge, D. J. Dunstan, David M. Hunt, Martin J. Warren   +5 more
openalex   +2 more sources

Bridging Green Chemistry and Circular Economy: A Pathway to Sustainable Polyester Plastics Through Feedstock, Synthesis, and Waste Upcycling

Advanced Science, EarlyView.
This review summarizes green and low‐carbon strategies throughout the entire life cycle of polyester plastics, including sustainable monomer synthesis, optimization polymerization, efficient recycling, and advanced upcycling technologies. The synergistic implementation of these strategies is expected to significantly promote the development of a ...
Jinzhou Li, Junliang Chen, Yingbing Zhang, Li Wang, Pin Gao, Jianping Yang   +5 more
wiley   +1 more source

Kinetic mechanism of glucose-6-phosphate dehydrogenase from the lactating rat mammary gland. Implications for regulation.

, 1980
David S. Shreve, Haim Levy
openalex   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Predictive value of the combined evaluation of the neutrophil-to-lymphocyte ratio and lactate dehydrogenase level for coronary artery lesions in patients with acute Kawasaki disease. [PDF]

Ital J Pediatr
Li L, Wan Y, Li GA, Tao SS.
europepmc   +1 more source