Results 251 to 260 of about 785,757 (422)

Tumor‐associated macrophages regulate the function of cytotoxic T lymphocyte through PD‐1/PD‐L1 pathway in multiple myeloma

Cancer Medicine, Volume 11, Issue 24, Page 4838-4848, December 2022., 2022
Tumor‐associated macrophages(TAMs) are a vital constituent of the tumor microenvironment and involved in the immunological escape of vicious clonal plasma cells of myeloma patients. Our research shows that CSF1R can regulates the production of TAMs while the PD‐1/PD‐L1 pathway regulates the effect of TAMs on cytotoxic T lymphocyte. It may provide a new
Jiangbo Zhang, Zhaoyun Liu, Panpan Cao, Hao Wang, Hui Liu, Luoming Hua, Hua Xue, Rong Fu   +7 more
wiley   +1 more source

Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer. [PDF]

Cell Commun Signal
Naik A, Thomas R, Al-Khalifa A, Qasem H, Decock J.   +4 more
europepmc   +1 more source

Some properties of lactate dehydrogenase found in human urine [PDF]

, 1967
D.T. Plummer, P. D. Leathwood
openalex   +1 more source

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Advanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang, Ruizhi Lai, Xinpei Wang, Xu Chen, Youjian Zhou, Shengbin Li, Xiaohui Qiu, Zekai Zeng, Jianye Yuan, Jinghuan Mao, Zhidong Chen, Junqing Wang   +11 more
wiley   +1 more source

Phase 2 results of lisocabtagene maraleucel in Japanese patients with relapsed/refractory aggressive B‐cell non‐Hodgkin lymphoma

Cancer Medicine, Volume 11, Issue 24, Page 4889-4899, December 2022., 2022
This analysis assessed safety and efficacy of lisocabtagene maraleucel (liso‐cel), an autologous CD‐19‐directed CAR T‐cell product, in Japanese patients with R/R aggressive LBCL in Cohort 3 of TRANSCEND WORLD (NCT03484702). Liso‐cel demonstrated meaningful efficacy and a manageable safety profile in Japanese patients with R/R LBCL.
Shinichi Makita, Go Yamamoto, Dai Maruyama, Yuki Asano‐Mori, Daisuke Kaji, Revathi Ananthakrishnan, Ken Ogasawara, Lara Stepan, Claudia Schusterbauer, Nils Rettby, Jens Hasskarl, Koji Izutsu   +11 more
wiley   +1 more source

Serum Lactate Dehydrogenase Levels: The Grim Reaper Sign in Acute Pancreatitis? [PDF]

J Community Hosp Intern Med Perspect
Trad G, Hoekstra J, Haddadin R, Shetty K, Ryan J.   +4 more
europepmc   +1 more source

Enzyme Studies in Cerebral Tumours. Lactate Dehydrogenase, Glucose Phosphate Isomerase, Acid and Alkaline Phosphatase in Plasma, Ventricular Cerebrospinal Fluid and Tumour Cyst Fluid from Cases of Glioma and Cerebral Secondary Carcinoma

, 1965
Monamy Buckell, May C. Robertson
openalex   +1 more source

Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

Advanced Science, EarlyView.
The MOF material UIO‐66‐NH2 is functionalized with DBCO groups on its surface, encapsulating NO‐prednisolone and conjugating it with azide‐modified IL‐10. Finally, the complex is extruded with MM to form biomimetic functional nanoparticles. Upon intra‐articular injection, MI@UN, enveloped by the MM, specifically targets synovial macrophages, is ...
Wenwei Li, Yang Liu, Ming Wei, Zhichao Yang, Zhaoyu Li, Zezhong Guo, Liang Yan, Yang Lu, Hao Tang, Bofeng Li, Wei Huang   +10 more
wiley   +1 more source

Lactate Dehydrogenase-A-Forming LDH5 Promotes Breast Cancer Progression. [PDF]

Breast Cancer (Dove Med Press)
Fang T, Hu L, Chen T, Li F, Yang L, Liang B, Wang W, Zeng F.   +7 more
europepmc   +1 more source

Lactate dehydrogenase in synovial fluid diagnostic evaluation of total activity and isoenzyme patterns. [PDF]

, 1968
E M Veys, R.J. Wieme
openalex   +1 more source