Results 71 to 80 of about 231,763 (293)

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

open access: yesAdvanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang   +8 more
wiley   +1 more source

Total discrimination of peritoneal malignant ascites from cirrhosis- and hepatocarcinoma-associated ascites by assays of ascitic cholesterol and lactate dehydrogenase [PDF]

open access: bronze, 1994
Giuseppe Castaldo   +9 more
openalex   +1 more source

Impact of serum lactate dehydrogenase on the short-term prognosis of COVID-19 with pre-existing cardiovascular diseases [PDF]

open access: bronze, 2021
Akiko Masumoto   +15 more
openalex   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

open access: yesAdvanced Science, EarlyView.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin   +15 more
wiley   +1 more source

Comparative evaluation of lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels in periodontal diseases

open access: yesمجله دانشکده دندانپزشکی اصفهان, 2011
Introduction: Periodontitis is a chronic multi-factorial infectious disease characterized by irreversible destruction of collagen fibers and other matrix constituents of the gingival tissues and periodontal ligament, and resorption of alveolar bone ...
Arash Azizi   +3 more
doaj  

Mitochondrial disorders in neuromuscular pathology

open access: yesНервно-мышечные болезни, 2019
Introduction. With the advent of new drugs — analogues of mitochondrial metabolites, the widespread introduction into practice of research methods for assessing the function of mitochondria in patients with neurological pathology and other diseases ...
S. V. Kotov   +2 more
doaj   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

open access: yesAdvanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen   +11 more
wiley   +1 more source

Impact of lactate dehydrogenase on prognosis of patients undergoing cardiac surgery [PDF]

open access: gold, 2022
Yu Zeng   +7 more
openalex   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

open access: yesAdvanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge   +21 more
wiley   +1 more source

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