Results 31 to 40 of about 85,812 (297)

The Effect of Visual Speed Swimming Control in Swimmers’ Threshold Training

Central European Journal of Sport Sciences and Medicine, 2018
Controlling swimming speed is an important factor as far as accomplishing swimming training tasks is concerned. The aim of this study was to determine the importance of visual information about control of swimming speed in threshold training for swimmers.
Stefan Szczepan, Krystyna Zatoń, Jacek Borkowski   +2 more
doaj   +1 more source

Lactacidemia during track day motorcycle racing competitions

Annales Kinesiologiae, 2020
Introduction: Motorbike racing is one of the most dangerous sports due to high speeds, and it is highly demanding on racers both mentally and physically.
Marcelo Conte, João Vitor de Souza, Gustavo Azevedo, Victor Fernandes   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Impact of rapid lactate clearance as an indicator of hemodynamic optimization on outcome in out-of-hospital cardiac arrest: A retrospective analysis.

PLoS ONE, 2019
OBJECTIVE:We analyzed the impact of rapid lactate clearance as an indicator of hemodynamic optimization on the outcome of out-of-hospital cardiac arrest (OHCA) during early post-cardiac arrest care (PCAC). METHODS:This retrospective analysis was based on
Kap Su Han, Su Jin Kim, Eui Jung Lee, Kyoung Yae Park, Ji Young Lee, Sung Woo Lee   +5 more
doaj   +1 more source

The Maximal Lactate Steady State Workload Determines Individual Swimming Performance

Frontiers in Physiology, 2021
The lactate threshold (LT) and the strongly related maximal lactate steady state workload (MLSSW) are critical for physical endurance capacity and therefore of major interest in numerous sports. However, their relevance to individual swimming performance
Gernot O. Hering, Jens Stepan, Jens Stepan   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Post-analysis methods for lactate threshold depend on training intensity and aerobic capacity in runners. An experimental laboratory study

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: This study aimed to evaluate different mathematical post-analysis methods of determining lactate threshold in highly and lowly trained endurance runners.
Tiago Lazzaretti Fernandes, Rômulo dos Santos Sobreira Nunes, Cesar Cavinato Cal Abad, Andrea Clemente Baptista Silva, Larissa Silva Souza, Paulo Roberto Santos Silva, Cyro Albuquerque, Maria Cláudia Irigoyen, Arnaldo José Hernandez   +8 more
doaj   +1 more source

Is there an acute exercise-induced physiological/biochemical threshold which triggers increased speed of cognitive functioning? A meta-analytic investigation

Journal of Sport and Health Science, 2015
Purpose: The purpose of this study was to examine, using meta-analytic measures, the evidence regarding the optimal exercise intensity at which improvements in speed of cognitive function are triggered.
Terry McMorris, Beverley J. Hale
doaj   +1 more source

Threshold for muscle lactate accumulation during progressive exercise

, 1989
The purpose of this study was to investigate the relationship between muscle and blood lactate concentrations during progressive exercise. Seven endurance-trained male college students performed three incremental bicycle ergometer exercise tests.
R. A. Robergs, D. L. Costill, Costill, D.L., W. J. Fink, Chwalbinska-Moneta, J., Robergs, R.A., J. Chwalbinska-Moneta, Fink, W.J.   +7 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source