Results 91 to 100 of about 81,911 (253)

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

Modeling lactate threshold in young squad athletes: influence of sex, maximal oxygen uptake, and cost of running. [PDF]

Eur J Appl Physiol, 2023
Ji S, Keller S, Zwingmann L, Wahl P.
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Lactate Threshold and Psychomotor Fatigue Threshold in Hot Conditions: Suggestions for Soccer Players Participating in the Qatar World Cup 2022. [PDF]

Int J Environ Res Public Health, 2022
Konefał M, Chmura J, Charmas M, Kotowska J, Błażejczyk K, Chmura P.   +5 more
europepmc   +1 more source

Validation of aerobic threshold assessment using a sweat lactate sensor during arm crank exercise by healthy adults

Physiological Reports
Assessment of the aerobic threshold (AeT) using a sweat lactate sensor has been validated primarily during lower limb exercise. This study aimed to examine whether sweat‐based AeT assessment is also applicable during upper limb exercise.
Tomonori Sawada, Hiroki Okawara, Kazuki Minami, Shintaro Narushima, Ayaka Shiratori, Yoshinori Katsumata, Masaya Nakamura, Takeo Nagura, Daisuke Nakashima   +8 more
doaj   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source

Threshold estimation in running using dynamical correlations of RR intervals

Physiological Reports
We study the estimation of aerobic threshold (AeT) and anaerobic threshold (AnT) using dynamical detrended fluctuation analysis (DDFA). Conventionally, the thresholds are estimated in laboratory settings, where the subject performs an incremental ...
Matias Kanniainen, Vesa Laatikainen‐Raussi, Teemu Pukkila, Krista Vohlakari, Esa Hynynen, Johanna K. Ihalainen, Esa Räsänen   +6 more
doaj   +1 more source

Lactate Profiling and the Agreement Among Various Lactate Threshold Methods in Professional and Youth Soccer Players

Applied Sciences
The lactate threshold (LT) and the associated running velocities are important markers used to define physical readiness and prescribe exercise intensity in athletes. This study examined blood LT during maximal cardiopulmonary exercise testing using four
Marcos Michaelides, Koulla Parpa
doaj   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source