Results 61 to 70 of about 930,544 (280)
Physiological consequences of the work of breathing and of inspiratory muscle training [PDF]
, 2009 A reduced blood lactate concentration ([lac-]B) is commonly observed during whole-body exercise following inspiratory muscle training (IMT). However, whether the inspiratory muscles are, in part, the source of these reductions remains unknown ...
Brown, Peter Ian, Brown, P
core
, 1989 The purpose of this paper is to review the delicate metabolic balance an endurance athlete must maintain to achieve a desirable performance. The optimum pace is ultimately determined by the athlete\u27s ability to deliver large volumes of oxygen to the ...
Kelly, John M., D.P.E.
core +2 more sources
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
Acute hypoxia alters lactate threshold in chronic altitude residents [PDF]
, 2004 At an identical workload, blood lactate concentration ([La]) is higher in acute hypoxia (H) versus normoxia (N). However, in altitude-acclimatized individuals, the lactate response to incremental exercise in H and with various VO2max protocols is less ...
Ghiasvand, F. +2 more
core
Prediction of aerobic and anaerobic capacity from lactate relative change during isocapnic buffering phase in elite athletes [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2013 Purpose: The aim of this study was to investigate the prediction of aerobic and anaerobic capacity from lactate relative change during isocapnic buffering phase in elite athletes. Methods: eight endurance and six sprint elite cyclists participated in the
روح الله نیکویی +1 more
doaj +1 more source
TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes
Advanced Science, EarlyView.In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang +11 more
wiley +1 more source
Development of the simplified method for estimating lactate threshold.
The Annals of physiological anthropology, 1986 The true response according to the concept of "anaerobic threshold" during a progressive incrementalload exercise, corresponds to the onset of blood lactate accumulation from a resting level, and it is called lactate threshold (LT). The measurement and analysis of blood lactate, however, is complicated and not popular, so LT is often estimated by 2 ...
FUKUBA, Yoshiyuki +4 more
openaire +3 more sources
Advanced Science, EarlyView.Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang +3 more
wiley +1 more source
Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair
Advanced Science, EarlyView.We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing +10 more
wiley +1 more source
A mathematical model of the human respiratory system during exercise [PDF]
, 2009 This paper describes a respiratory control system model and the associated computer simulations for human subjects during incremental exercise, involving work rates from zero up to the highest level in the heavy exercise domain.
Thamrin, H., Murray-Smith, D.J.
core +4 more sources