Results 51 to 60 of about 214,124 (306)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Use of baby food products during the complementary feeding period: What factors drive parents' choice of products?

Maternal and Child Nutrition
It is recommended that infants are introduced to complementary foods from 6 months old, moving from a solely milk diet to eating a family diet by 12 months old. Although home cooking of family foods is recommended, a rapidly growing market producing baby
Grace Hollinrake, Sophia Komninou, Amy Brown   +2 more
doaj   +1 more source

Parenteral micronutrient supplementation enhances mammary immune function and colostrum–milk quality by modulating cytokine profiles and oxidative stress in transition crossbred cows

Frontiers in Immunology
BackgroundThe transition period in dairy cattle is marked by oxidative stress and immune suppression linked to altered micromineral status. This study evaluated whether parenteral supplementation with trace elements and vitamins could enhance mammary ...
Yallappa M. Somagond, Yallappa M. Somagond, Pravasini Das, Ajay Kumar Dang, Dhawal K. Yadav, Priyanka M. Kittur, Bibhudatta S.K. Panda, Pooja Devi, Aarti Kamboj, Mohanned Naif Alhussien   +9 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Proteomic analysis of Buffalo milk somatic cells reveals metabolomic and immunological transitions during early lactation

Scientific Reports
Buffalo milk is renowned for its nutritional and functional properties. Milk somatic cells protect the mammary gland, contribute to the functionality of the udder, and also aid in the health and development of newborn calves, particularly during the ...
Priyanka M. Kittur, Lija Satheesan, Narasimha Tanuj Gunturu, Yallappa M. Somagond, A. P. Madhusoodan, Ravi Kumar Gandham, Rani Alex, Ajay Kumar Dang   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The safety of at home powdered infant formula preparation: A community science project

Maternal and Child Nutrition
Formula fed infants experience gastrointestinal infections at higher rates than breastfed infants, due in part to bacteria in powdered infant formula (PIF) and bacterial contamination of infant feeding equipment.
Aimee Grant, Sara Jones, Vicky Sibson, Rebecca Ellis, Abbie Dolling, Tara McNamara, Jonie Cooper, Susan Dvorak, Sharon Breward, Phyll Buchanan, Emma Yhnell, Amy Brown   +11 more
doaj   +1 more source

Lactation failure in crossbred Sahiwal Friesian cattle

, 2001
Milk producers in Malaysia make extensive use of crossbred Sahiwal Friesian dairy cattle. These animals have, however, been found susceptible to lactation failure. A survey of cows in an experimental herd of F1 Sahiwal Friesian animals indicated that, in
Murugaiyah, M., Wilde, C.J., Sheikh Omar, A.R., Ramakrishnan, P., Knight, C.H.   +4 more
core   +1 more source

Genetic Relationship of Body Energy and Blood Metabolites with Reproduction in Holstein Cows [PDF]

, 2008
Body condition score (BCS), energy content (EC), cumulative effective energy balance (CEEB), and blood serum concentrations of glucose, beta-hydroxybutyrate (BHBA), and nonesterified fatty acids ( NEFA) were measured throughout first lactation in 497 ...
Arsenos, G., Zygoyiannis, D., Oikonomou, G., Valergakis, G. E., Banos, G., Tsiaras, A.   +5 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source