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Response to lactate infusion in generalized anxiety disorder
Biological Psychiatry, 1988Intravenous sodium lactate infusion provokes symptoms of panic in patients with panic disorder at a significantly higher rate than in normal controls. Lactate sensitivity has been postulated to be specific for patients with panic attacks regardless of frequency of attacks or coexisting diagnoses.
D S, Cowley +4 more
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Substance Use Disorders in Pregnancy and Lactation
2021Women use substances and, for some, this use continues during pregnancy. It is not uncommon for women with substance use disorders to have a co-occurring mental health condition. Women who have substance use disorders and/or mental health disorders during and after pregnancy often face tremendous stigma and discrimination that impacts their ability to ...
Elisabeth Johnson, Susan Myers
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Lactate: A New Target for Brain Disorders
NeuroscienceLactate in the brain is produced endogenously and exogenously. The primary functional cells that produce lactate in the brain are astrocytes. Astrocytes release lactate to act on neurons, thereby affecting neuronal function, through a process known as the astrocyte-neuron shuttle.
Shunfeng Liu, Shouhong Zhou
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Biological correlates of lactate sensitivity in panic disorder
Biological Psychiatry, 1989In this pilot study, 9/9 patients with panic disorder experienced a lactate-induced panic attack as compared with 0/9 controls. Baseline measurements were significant for higher anxiety self-ratings, higher heart and respiratory rates, elevated potassium, and lower lymphocyte 3H-dihydroalprenolol (DHA) binding in the patient group.
T A, Aronson +3 more
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The Diagnostic Utility of Lactate Sensitivity in Panic Disorder
Archives of General Psychiatry, 1990Lactate infusion is the most extensively studied of the pharmacological challenge tests in panic disorder. We assessed the value of this test in the diagnosis and subtyping of panic in clinical and research settings. Analysis of lactate infusion studies to date suggests that patients with panic attacks are significantly more sensitive to lactate than ...
D S, Cowley, G W, Arana
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Calcium and Bone Disorders During Pregnancy and Lactation
Endocrinology and Metabolism Clinics of North America, 2006Adaptations in mineral metabolism occur during pregnancy and lactation, and these adaptations uniquely affect the presentation, diagnosis, and management of disorders of calcium and bone metabolism. Maternal adaptations to pregnancy and lactation have evolved differently over time, such that dietary calcium absorption dominates in pregnancy, whereas ...
Christopher S, Kovacs +1 more
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Prescribing for psychiatric disorders in pregnancy and lactation
Best Practice & Research Clinical Obstetrics & Gynaecology, 2001The most recent Confidential Enquiry into the causes of maternal deaths during the perinatal period in England and Wales (1994–1996) revealed that psychological illness was at least as important as hypertensive disorders. It is therefore important for obstetricians to be aware of a variety of psychiatric conditions as well as the psychotropic ...
Craig, M, Abel, K
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Hyperventilation and lactate metabolism in panic disorder
Biological Psychiatry, 1989392 elderly subjects (ages 60-79) were administered a battery of tests of memory and attention to assess the acute and chronic effects of placebo, 2.5 mg and 10 mg diazepam. The elderly showed increased sensitivity to the adverse acute effects of a single dose on some performance measures (not attributable to differences in plasma drug concentration ...
Richard Maddock, Cameron Carter
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Clinical Presentations of Breast Disorders in Pregnancy and Lactation
2020The breast tissue undergoes significant physiological change during pregnancy and lactation. These changes can give rise to some unique disorders during pregnancy , puerperium and lactation or exaggerate pre-existing conditions. Clinical examination becomes less reliable due to textural change and density of breast tissue as a result of hormonal ...
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Effect of Flumazenil in Lactate-Sensitive Patients With Panic Disorder
American Journal of Psychiatry, 1998Flumazenil is a benzodiazepine receptor antagonist that has been reported to provoke panic attacks in patients with panic disorder. This study was undertaken to compare the effects of flumazenil and sodium lactate, the most widely studied panic provocation agent.Ten patients with panic disorder were given infusions of saline, sodium lactate, and ...
Ströhle, A. +4 more
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