Results 41 to 50 of about 1,446,122 (309)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Quantification of sleep in dairy cows in three different stages of lactation [PDF]

open access: yes, 2011
The aim of this project was to quantify the total sleep time in modern dairy cows during 24-hour periods and to investigate whether the total amount of sleep as well as time spent in different sleep stages varies between the dry period, early- and peak ...
Nilsson, Emma
core   +1 more source

Experience of using plant complexes in physiological completion of lactation

open access: yesРепродуктивная эндокринология, 2021
Ending breastfeeding is often quite a challenge for women, justifying the need for qualified medical counseling and accompaniment by a doctor. Quite frequently during weaning the baby, women complain about pain, discomfort and swelling of the breasts ...
N. V. Kosei   +3 more
doaj   +1 more source

Cerebrospinal fluid lactate concentrations in dogs with seizure disorders [PDF]

open access: yesJournal of Veterinary Internal Medicine, 2020
Abstract Background Cerebrospinal fluid (CSF) lactate concentrations increase after seizure activity in many human patients independent of the underlying disease process. The effect of seizure activity on CSF lactate concentration in dogs is unknown.
Christopher L. Mariani   +11 more
openaire   +2 more sources

Clinical pharmacy considerations in special population: Pregnancy and lactation

open access: yes, 2019
The physiological changes that occur during pregnancy and lactation may affect pharmacokinetics and pharmacodynamics of drugs. Hence, administration of medications during pregnancy and lactation may require adjustments in dose, duration, or frequency. In
Ibrahim, Angham   +4 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Longevity of buffalo cows and reasons for their culling

open access: yesItalian Journal of Animal Science, 2010
Subject of investigation were 565 buffalo cows from the Bulgarian Murrah breed, raised at the Agricultural Institute – Shumen for the period 1989-2003.
Y. Ilieva, T. Peeva
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Abortion Effects on Production, Reproductive Performance, and Health of Dairy Cattle

open access: yesActa Veterinaria Eurasia
In order to investigate the consequences of abortions on dairy cattle performance, records from the software of seven dairy farms in Argentina were studied between February 2015 and June 2019.
Víctor Humberto SUAREZ   +2 more
doaj   +1 more source

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