Results 61 to 70 of about 44,362 (300)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Clinical pharmacy considerations in special population: Pregnancy and lactation

, 2019
The physiological changes that occur during pregnancy and lactation may affect pharmacokinetics and pharmacodynamics of drugs. Hence, administration of medications during pregnancy and lactation may require adjustments in dose, duration, or frequency. In
Ibrahim, Angham, Owusu, Yaw B., Sankaralingam, Sowndramalingam, Awaisu, Ahmed, Al Saad, Doua Tayser Sulieman   +4 more
core   +1 more source

Initial difficulties with breastfeeding technique and the impact on duration of exclusive breastfeeding

Revista Brasileira de Saúde Materno Infantil
Objectives: the present study aimed to evaluate the influence of initial difficulties in breastfeeding on duration of exclusive breastfeeding. Methods: a prospective study with follow up of nursing mothers and their babies in the first six months of age.
Gessandro Elpídio Fernandes Barbosa, Janeide M. Pereira, Marianne S. Soares, Luciana Barbosa Pereira, Lucinéia Pinho, Antônio Prates Caldeira   +5 more
doaj   +1 more source

Cumulative Incidence of Locomotor Disorders in Dairy Herds of Tehran Province [PDF]

Iranian Journal of Veterinary Surgery, 2013
Objective- Locomotor disorders are prevalent health problems in dairy herds that negatively affect milk production, reproduction performance and animal welfare.
Hamid Sharifi, Nima Ghalekhani, Mahshid Hashemi, Zohre Abbaspour-Benhengi, Hanie Rahimifard, Saeid Tabatabaei, Saeedeh Shojaeipour, Parham Razavi, Fereshte Kavousi   +8 more
doaj  

The Maternal Brain: An Organ with Peripartal Plasticity

Neural Plasticity, 2014
The time of pregnancy, birth, and lactation, is characterized by numerous specific alterations in several systems of the maternal body. Peripartum-associated changes in physiology and behavior, as well as their underlying molecular mechanisms, have been
Katharina Maria Hillerer, Volker Rudolf Jacobs, Thorsten Fischer, Ludwig Aigner   +3 more
doaj   +1 more source

Non-additive QTL mapping of lactation traits in 124,000 cattle reveals novel recessive loci

Genetics Selection Evolution, 2022
Background Deleterious recessive conditions have been primarily studied in the context of Mendelian diseases. Recently, several deleterious recessive mutations with large effects were discovered via non-additive genome-wide association studies (GWAS) of ...
Edwardo G. M. Reynolds, Thomas Lopdell, Yu Wang, Kathryn M. Tiplady, Chad S. Harland, Thomas J. J. Johnson, Catherine Neeley, Katie Carnie, Richard G. Sherlock, Christine Couldrey, Stephen R. Davis, Bevin L. Harris, Richard J. Spelman, Dorian J. Garrick, Mathew D. Littlejohn   +14 more
doaj   +1 more source

Diagnosis and Therapy of Psychosomatic Disorders in Reproductive Cycle of Women in General Medical Practice (Review)

Архивъ внутренней медицины, 2022
The incidence of different psychiatric disorders (affective, anxious, dysmorphic, psychotic) during menstruation, pregnancy and the postpartum period reaches 80 %.
V. E. Medvedev
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source