Results 91 to 100 of about 2,083,504 (286)
Advanced Science, EarlyView.A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang +11 more
wiley +1 more source
Ciência e Agrotecnologia, 2006 Por meio de análises uni e bicaracterísticas entre a produção total de leite (PL), produção de gordura (PROG), porcentagem de gordura (PERG), duração da lactação (DL) e período seco (PSECO), objetivou-se, com este trabalho, estimar parâmetros genéticos ...
Marcos Vinicius Gualberto Barbosa Silva +5 more
doaj +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Advanced Science, EarlyView.In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang +6 more
wiley +1 more source
Modelling temperature effects on milk production : a study on Holstein cows at a Japanese farm [PDF]
, 2014 Milk yield and its composition vary according to individual cows as well as to a variety of different environment conditions, such as temperature.
Machiko Yano +5 more
core +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2006 Utilizou-se o método dos quadrados mínimos para avaliar os efeitos da composição genética (CG) e dos fatores de meio sobre a produção total de leite (PL), duração da lactação (DL) e produção de leite por dia de intervalo de partos (P/I) (n=2.016) de 822 ...
J.R. Glória +4 more
doaj +1 more source
Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li +15 more
wiley +1 more source
LACTATING LENGTH AND ITS BEHA VIOUR IN NILI-RAVI BUFFALOES
Pakistan Veterinary Journal, 2000 Behaviour of lactation length in Nili-Ravi buffaloes and its relationship with other economic traits was studied using 2704 lactations of 993 buffaloes. Lactations shorter than eight weeks were not included in the data set.
M.S. Khan and H.Z. Chaudhry
doaj
Revista Brasileira de Zootecnia, 2010 The objective of this work was to evaluate milk production of a Holstein × Zebu herd managed on a semiintensive system at Estação Experimental Joaquim Távora, IAPAR, in the northeastern region of Paraná - Brazil. Two hundred and seventeen records on
Daniel Perotto +2 more
doaj +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source