Results 141 to 150 of about 2,179,464 (293)

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

open access: yesAdvanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang   +10 more
wiley   +1 more source

The Effect of Some Reproductive and Productive Traits on Lactation Performance of Butana Cattle at Atbara Reseach Station

open access: yes, 2004
This study was conducted to assess the effect of calving interval, age at first calving, lactation length and parity number on lactation yield, first 100-day milk yield & first 180-day milk yield on the 2nd and 3rd lactation of Butana cattle of the ...
Bent Whab Abd El-whab, Amna
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The In Situ Electrochemical−Chemical Cascade Strategy for Pyruvic Acid Synthesis

open access: yesAdvanced Science, EarlyView.
By employing an “unsaturation−oxygen coordination engineering” strategy, the local coordination environment is regulated to achieve efficient electrochemical synthesis of H2O2. Importantly, an electrochemical−chemical coupled cascade strategy is utilized for the efficient preparation of pyruvic acid via lactic acid oxidation. ABSTRACT Hydrogen peroxide
Xueli Mei   +6 more
wiley   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

open access: yesAdvanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu   +12 more
wiley   +1 more source

Influences on Lactation Length and the Timing of Weaning Events in Colobus vellerosus

open access: yes, 2016
I explored variation in maternal investment strategies. I investigated whether infant sex, food availability, female feeding competition or infanticide risk influenced lactation length, the context of nursing cessation and the extent to which mothers can simultaneously gestate and lactate in a wild colobine.
openaire   +2 more sources

Lactation Length and Lactation Milk Yield in Cattle in Sudan

open access: yes, 2008
This study was conducted to compare some productive traits of imported versus locally bred and crossbred dairy cows (50, 56.5 and 62.5%) in 2 different farms in Khartoum, Sudan.
IE.O. Amasaib, 2H.E. Mohamed   +1 more
core  

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

open access: yesAdvanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu   +10 more
wiley   +1 more source

Ovarian responses to lactation management strategies

open access: yes, 2009
A number of lactation management strategies can be applied to reduce negative effects of lactation on post-weaning fertility. This paper focuses on effects of lactation length, Intermittent Suckling and Split Weaning on follicle development and ...
Kemp, B.   +4 more
core  

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian   +11 more
wiley   +1 more source

A Study on Some Non-genetic Factors and Their Impact on Milk Yield and Lactation Length of Sudanese Nubian Goats

open access: yes, 2010
: The objective of the current study was to estimate some productive parameters of Sudanese Nubian goat under extensive management system. The data eighty-six parities of Sudanese Nubian goats were used; these parities were occurred during the period ...
El-Abid   +3 more
core  

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