Results 121 to 130 of about 2,048,354 (300)

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu   +15 more
wiley   +1 more source

Reproductive performance in high-producing dairy cows [PDF]

open access: yes, 2008
Milk yields >10,000 kg/year are common in modern dairy production, owing to improved nutrition, management and genetic gains through use of progeny-tested bulls.
Rodriguez-Martinez, Heriberto   +15 more
core   +1 more source

Comparative study on apparent digestibility of nutrients, rumen fermentation parameters and milk quality of high-yielding and low-yielding dairy cows in different physiological periods

open access: yesSiliao yanjiu, 2021
The experiment studied the effect of lactation performance and lactation stages on the apparent digestibility of nutrients, rumen fermentation parameters and milk quality of dairy cows. The experiment adopted a two-factor experimental design.
Shou-qian ZHU   +5 more
doaj  

Milk composition and blood metabolic profile from holstein cows at different calving orders and lactation stages

open access: yesActa Scientiarum: Animal Sciences, 2017
This study aimed to evaluate milk composition and metabolic profile of Holstein cows at different calving orders in the beginning, middle, and end of lactation.
Mariana Borges de Castro Dias   +5 more
doaj   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao   +7 more
wiley   +1 more source

The Effect of Calf Gender on Milk Production in Seasonal Calving Cows and Its Impact on Genetic Evaluations.

open access: yesPLoS ONE, 2016
Gender of the calf whose birth initiates lactation could influence whole lactation milk yield of the dam due to hormonal influences on mammary gland development, or through calf gender effects on gestation length.
Melanie K Hess   +2 more
doaj   +1 more source

Severity of mastitis symptoms as a predictor of C-reactive protein in milk and blood during lactation [PDF]

open access: yes, 2006
OBJECTIVE: To investigate the presence of C-reactive protein (CRP) in breast milk and any relationship between changes in CRP in breast milk and blood, and the severity of systemic and breast symptoms experienced during mastitis. METHODS: Mothers (n = 26)
Fetherston, C.M.   +2 more
core  

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu   +14 more
wiley   +1 more source

Chrysanthemum Morifolium–Derived Nanovesicles Reduce Lactate‐Associated Histone Lactylation and Modulate Microglia‐Mediated Neuroinflammation in Sepsis‐Associated Encephalopathy

open access: yesAdvanced Science, EarlyView.
When used to treat sepsis‐associated encephalopathy, Chrysanthemum morifolium–derived nanovesicles can inhibit the H3K18la/NF‐κB axis to regulate microglia‐mediated neuroinflammation. ABSTRACT Sepsis‐associated encephalopathy (SAE)—a complication of the central nervous system in patients with sepsis—markedly diminishes cognitive functions and is linked
Kaiqiang Li   +11 more
wiley   +1 more source

Performance of dairy cows and calves in agro-pastoral production systems [PDF]

open access: yes, 2013
Seasonal changes in pasture quality and quantity and cattle management routines were examined on 10 farms in southwest Uganda in order to evaluate how these factors affected milk yield, live weight and body condition in cows and daily weight gain in ...
Johansson, Christina
core   +1 more source

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