Results 261 to 270 of about 5,356,068 (315)

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Production of improved Ethiopian Tej using mixed lactic acid bacteria and yeast starter cultures. [PDF]

Sci Rep
Denekew K, Tigu F, Birri DJ, Ashenafi M, Bai FY, Desalegn A.   +5 more
europepmc   +1 more source

Multiscale Construction, Evaluation, and Application of Organoids

Advanced Science, EarlyView.
Organoids are pivotal models with transformative biomedical potential. A comprehensive multi‐scale perspective is presented, encompassing dual‐scale construction, four‐dimensional evaluation, triple‐point application, and an analysis of the current challenges faced by organoid technology, aiming to advance organoid research and its biomedical ...
Wanting Ma, Zhenglin Dong, Zhu'anzhen Zheng, Long Bai, Xingcai Zhang, Jiacan Su   +5 more
wiley   +1 more source

Probiotic Potential of Lactic Acid Bacteria Isolated from Moroccan Traditional Food Products. [PDF]

Microorganisms
Yao AOP, Mounir M, Razafindralambo H, Jacques P.   +3 more
europepmc   +1 more source

Lignin‐Containing Nanocellulose Mediated Interlayer Modulation Unlocks Stable and Redispersible MXene

Advanced Science, EarlyView.
Amphiphilic lignin‐containing nanocellulose (LNC) establishes competitive interactions between MXene nanosheets, enabling precise modulation of interlayer spacing and interfacial chemistry. This strategy allows rapid fabrication of semi‐solid MXene via industrial‐scale spray drying, achieving long‐term reversible redispersibility and exceptional ...
Shuyang He, Zhen Yu, Shan Li, Shijie Lei, Lin Zhu, Ke Zhao, Fangxia Yang, Ningning Cao, Yuyan Liu, Zhimin Fan   +9 more
wiley   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

Influence of leaf morphological properties on epiphytic lactic acid bacteria counts in forage crops. [PDF]

PeerJ
Wu D, Tang G, Liu G, Sun T, Yang J, Tang G, Xu L.   +6 more
europepmc   +1 more source

Nanoparticle‐Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy

Advanced Science, EarlyView.
This study presents a nanoparticle‐embedded nanofiber (5F/STFM/R‐ES) to inhibit melanoma growth and reduce the risk of metastasis and recurrence. The drug delivery system induces ferroptosis and potentiates immunotherapy through resiquimod (R848) and Fe/Mn‐based metal‐polyphenol networks (TFM).
Mingyang Li, Rongrong Li, Baotong Xu, Yuhan Lian, Chenyu Yang, Jingwen Li, Junhao Liang, Linhan Ding, Dongsheng Zhang, Jing Guo, Xiao Fu   +10 more
wiley   +1 more source

Degradation of alkaloids and alkylamides in Zanthoxylum bungeanum meal by lactic acid bacteria via solid-state fermentation. [PDF]

AMB Express
Ullah F, Baichuan W, Yongjun Z, Rahman SU, Assefa M, Shah TA, Elossaily GM, Almohammed OA.   +7 more
europepmc   +1 more source