Results 331 to 340 of about 5,526,205 (386)

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang   +9 more
wiley   +1 more source

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

open access: yesAdvanced Science, EarlyView.
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie   +21 more
wiley   +1 more source

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

open access: yesAdvanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong   +16 more
wiley   +1 more source

“Lactic acid influences iron assimilation by a fungal pathogen via the iron reductive uptake pathway”

open access: yes
Gomes-Gonçalves A   +10 more
europepmc   +1 more source

Lactic Acid Bacteria (LAB) and Their Bacteriocins for Applications in Food Safety Against <i>Listeria monocytogenes</i>. [PDF]

open access: yesAntibiotics (Basel)
Piras C   +7 more
europepmc   +1 more source

Copper‐Based Nanotubes That Enhance Starvation Therapy Through Cuproptosis for Synergistic Cancer Treatment

open access: yesAdvanced Science, EarlyView.
We designed a copper‐based nanotube (NT) with copper ionophores to induce enhanced cuproptosis. In combination with starvation therapy, the NT significantly inhibited energy metabolism in HCC cells. Our results show that the depletion of GSH by Cu2+ intensified oxidative stress and cuproptosis, resulting in ROS generation and DLAT aggregation ...
Xuan Han   +8 more
wiley   +1 more source

Alopecia secondary to poly-L-lactic acid dermal fillers. [PDF]

open access: yesJAAD Case Rep
Nguyen KT   +4 more
europepmc   +1 more source

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