Results 1 to 10 of about 862 (134)

Serum sphingolipid profiling as a novel biomarker for metabolic syndrome characterization [PDF]

Frontiers in Cardiovascular Medicine, 2022
BackgroundSphingolipids are components of cell membrane structure, but also circulate in serum and are essential mediators of many cellular functions. While ceramides have been proposed previously as a useful biomarker for cardiometabolic disease, the ...
Loni Berkowitz, Cristian Salazar, Carol D. Ryff, Christopher L. Coe, Attilio Rigotti   +4 more
doaj   +2 more sources

Sphingolipid profiling as a biomarker of type 2 diabetes risk: evidence from the MIDUS and PREDIMED studies [PDF]

Cardiovascular Diabetology
Background Type 2 diabetes (T2D) has become a worldwide pandemic. While ceramides may serve as intermediary between obesity-related lipotoxicity and T2D, the relationship with simple glycosphingolipids remains uncertain.
Loni Berkowitz, Cristina Razquin, Cristian Salazar, Fiorella Biancardi, Ramón Estruch, Emilio Ros, Montserrat Fitó, Dolores Corella, Christopher L. Coe, Carol D. Ryff, Miguel Ruiz-Canela, Jordi Salas-Salvado, Daniel Wang, Frank B. Hu, Amy Deik, Miguel A. Martínez-Gonzalez, Attilio Rigotti   +16 more
doaj   +2 more sources

Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutation [PDF]

Journal of Lipid Research
Mutations in microtubule-associated protein Tau (MAPT), the gene that codes for the protein Tau, cause frontotemporal lobar degeneration (FTLD) with phenotypes ranging from behavioral changes to cognitive impairment and parkinsonism.
Almudena Maroto-Juanes, Thomas Vogels, Sascha Koppes-den Hertog, Maarten Loos, Dieter Lütjohann, Martin Giera, Rik van der Kant   +6 more
doaj   +2 more sources

Characterization of phospholipid profiles of egg yolks: Newly classified plasmalogens, distribution of polyunsaturated fatty acids, and the effects of dietary enrichment [PDF]

Food Chemistry: X
Egg yolk phospholipids are commercially valuable products that are beneficial to human health. Previous research on phospholipids in egg yolk mainly focuses on phosphatidyl choline (PC), phosphatidyl ethanolamine (PE), and fatty acid compositions, and ...
Le Cheng, Xinlei Yuan, Ming Zhang, Jianguo Dong, Yao Wu, Rang Wang, Yixuan Li, Lishui Chen, Bing Fang   +8 more
doaj   +2 more sources

Cytokine-driven glycosphingolipid metabolism modulates endoplasmic reticulum calcium homeostasis in primary human renal mesangial cells [PDF]

Frontiers in Immunology
IntroductionGlycosphingolipids (GSLs), including hexosylceramides (HexCers), lactosylceramides (LacCers), and gangliosides composed of one or more sugar residues attached to ceramide, are essential components of cell membranes.
Mariia Stefanenko, Mariia Stefanenko, Tessa M. Ortiz, Sandra G. Mungaray, Mykhailo Fedoriuk, Oleg Palygin, Stefano Berto, Drew Moore, Tamara K. Nowling   +8 more
doaj   +2 more sources

Anxiety is associated with systemic pro-inflammatory profile and plasma lipid changes in Mexican young adults [PDF]

Frontiers in Cellular Neuroscience
IntroductionSystemic inflammation and altered lipid metabolism have been implicated in anxiety disorders, but the relationship between circulating cytokines, plasma lipid species and symptom severity remains unclear.MethodsWe studied 34 young adults (17 ...
Sofía Bernal-Vega, Sofía Bernal-Vega, Natalia Vázquez-Manjarrez, Mariana Villegas-Romero, Rocío Ortiz-López, José Alfonso Ontiveros-Sánchez de la Barquera, Antonio Alí Pérez-Maya, Alberto Camacho-Morales, Alberto Camacho-Morales   +8 more
doaj   +2 more sources

Plasma lipidomics, choline metabolites, and metabolic-associated steatotic liver disease (MASLD): A Coronary Artery Risk Development in Young Adults (CARDIA) study. [PDF]

PLoS ONE
Metabolic-associated steatotic liver disease (MASLD) is marked by accumulation of hepatic triacylglycerols (TAG), but many other lipids have been implicated.
Jessica K Sprinkles, Qiyao Qin, Charles Steward, Annie Green Howard, Anju Lulla, Autumn G Hullings, J Jeffrey Carr, Saame Raza Shaikh, Christy L Avery, Kari E North, Penny Gordon-Larsen, Katie A Meyer   +11 more
doaj   +2 more sources

Targeted analysis of sphingolipids and cytokines in plasma of dairy cows after calving reveals distinct impacts of systemic inflammation, ketosis, and mastitis [PDF]

Journal of Animal Science and Biotechnology
Background Sphingolipids (SL) are key regulators of inflammatory processes, yet their roles in dairy cows remain poorly understood. This study investigated the effects of inflammation (plasma haptoglobin concentration), ketosis, and mastitis on plasma SL
Elodie Lassallette, Alix Pierron Baysse, Blandine Gausseres, Gilles Foucras, Philippe Guerre   +4 more
doaj   +2 more sources

Transcriptomics pave the way into mechanisms of cobalt and nickel toxicity: Nrf2-mediated cellular responses in liver carcinoma cells [PDF]

Redox Biology
Cobalt (Co) and Nickel (Ni) are used nowadays in various industrial applications like lithium-ion batteries, raising concerns about their environmental release and public health threats. Both metals are potentially carcinogenic and may cause neurological
Alicia Thiel, Franziska Drews, Marcello Pirritano, Fabian Schumacher, Vivien Michaelis, Maria Schwarz, Sören Franzenburg, Tanja Schwerdtle, Bernhard Michalke, Anna P. Kipp, Burkhard Kleuser, Martin Simon, Julia Bornhorst   +12 more
doaj   +2 more sources

Circulating Lipoprotein Sphingolipids in Chronic Kidney Disease with and without Diabetes [PDF]

Biomedicines
Abnormalities of sphingolipid metabolism play an important role in diabetes. We compared sphingolipid levels in plasma and in isolated lipoproteins between healthy control subjects and two groups of patients, one with chronic kidney disease without ...
Maria F. Lopes-Virella, Samar M. Hammad, Nathaniel L. Baker, Richard L. Klein, Kelly J. Hunt   +4 more
doaj   +2 more sources