Results 111 to 120 of about 862 (134)
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Synthesis of fluorescent lactosylceramide stereoisomers
Chemistry and Physics of Lipids, 2006The intracellular distribution of synthetic glycosphingolipids (GSLs) bearing a fluorophore can be monitored in living cells by fluorescence microscopy. We reported previously that variation in the length of the long-chain base and in the structure of the carbohydrate-containing polar head group of (2S,3R) (or D-erythro-)-beta-lactosylceramide (LacCer)
Yidong, Liu, Robert, Bittman
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The Journal of Pediatrics, 1971
Fibroblasts were cultured from skin and bone marrow of a patient with an unusual neurovisceral lipid storage disease, characterized by the accumulation of lactosylceramide and a deficiency of lactosylceramide galactosyl hydrolase. The fibroblasts were found to manifest the defect both chemically and enzymically.
G, Dawson, R, Matalon, A O, Stein
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Fibroblasts were cultured from skin and bone marrow of a patient with an unusual neurovisceral lipid storage disease, characterized by the accumulation of lactosylceramide and a deficiency of lactosylceramide galactosyl hydrolase. The fibroblasts were found to manifest the defect both chemically and enzymically.
G, Dawson, R, Matalon, A O, Stein
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New Vis-Tas in Lactosylceramide Research
2014Lactosylceramide (LacCer) is a member of a large family of compounds collectively called the glycosphingolipids (GSL). These molecules are present in all mammalian cells, some bacteria and fungus. GSLs are composed of an amino acid serine, fatty acids and sugars and are usually localized on the cell surface wherein they serve as receptors for diverse ...
Subroto, Chatterjee +2 more
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Synthesis of double-labeled lactosylceramide
Glycoconjugate Journal, 1986The total stereo-controlled synthesis of lactosylceramide and introduction of two kinds of isotopes,3H and14C, into synthetic lactosylceramide are described.
Kimihiro Kanemitsu, Charles C Sweeley
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Astrocyte-derived lactosylceramide implicated in multiple sclerosis
Nature Medicine, 2014Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system. A new study has shown that the lipid lactosylceramide, produced by astrocytes, contributes to disease progression in a mouse model of MS.
Abdolmohamad, Rostami, Bogoljub, Ciric
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Effect of cholesterol on the lactosylceramide domains in phospholipid bilayers
Biophysical Journal, 2022Lactosylceramide (LacCer) in the plasma membranes of immune cells is an important lipid for signaling in innate immunity through the formation of LacCer-rich domains together with cholesterol (Cho). However, the properties of the LacCer domains formed in multicomponent membranes remain unclear.
Shinya Hanashima +6 more
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Lactosylceramide: a lipid second messenger in neuroinflammatory disease
Journal of Neurochemistry, 2007AbstractInflammatory disease plays a critical role in the pathogenesis of many neurological disorders. Astrogliosis and induction of pro‐inflammatory mediators such as chemokines, cytokines and inducible nitric oxide synthase (iNOS) are the ‘hallmarks’ of inflammatory disease.
Je-Seong, Won +2 more
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Lactosylceramide is required in apoptosis induced by N-Smase
Glycoconjugate Journal, 2006Lactosylceramide (LacCer) is a member of the glycosphingolipid family which has been recently recognized as a signaling intermediate in the regulation of cell proliferation and cell adhesion. In this paper, we present our studies pointing to a potential role of LacCer in inducing apoptosis.
Sergio F, Martin +2 more
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Targeting of lactosylceramide-containing liposomes to hepatocytes in vivo
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1983Incorporation of 8 mol% lactosylceramide in small unilamellar vesicles consisting of cholesterol, dimyristoylphosphatidylcholine and phosphatidylserine in a molar ratio of 5:4:1 and containing [3H]inulin as an aqueous-space marker resulted in a 3-fold decreased half-life of the vesicles in blood and a corresponding increase in liver uptake after ...
Spanjer, H.H., Scherphof, G.L.
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The Glycosphingolipid, Lactosylceramide, Regulates β1-Integrin Clustering and Endocytosis
Cancer Research, 2005Abstract Glycosphingolipids are known to play roles in integrin-mediated cell adhesion and migration; however, the mechanisms by which glycosphingolipids affect integrins are unknown. Here, we show that addition of the glycosphingolipid, C8-lactosylceramide (C8-LacCer), or free cholesterol to human fibroblasts at 10°C causes the ...
Deepak K, Sharma +5 more
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