Results 11 to 20 of about 862 (134)
Association of distinct microbial and metabolic signatures with microscopic colitis [PDF]
Nature CommunicationsMicroscopic colitis (MC) is a chronic inflammatory disease of the large intestine that primarily affects older adults and presents with chronic diarrhea.
Albert Sheng-Yin Chen +13 more
doaj +2 more sources
Metabolome Atlas of Brain Reveals Regional Shared and Unique Metabolic Drifts in Response to Type 2 Diabetes in Male Mice. [PDF]
FASEB JA detailed metabolome atlas of the male mouse brain was established, incorporating metabolomic and lipidomic profiling of seven anatomical regions. T2D induced marked metabolic alterations, which were mainly associated with lipotoxicity, defective energy metabolism, proinflammatory processes, and neurotoxicity.
Zhou Y +5 more
europepmc +2 more sources
Lactosylceramide: Lateral Interactions with Cholesterol [PDF]
Biophysical Journal, 2006 Lactosylceramide (LacCer) is a key intermediate in glycosphingolipid metabolism and is highly enriched in detergent-resistant biomembrane fractions associated with microdomains, i.e., rafts and caveolae. Here, the lateral interactions of cholesterol with LacCers containing various homogeneous saturated (8:0, 16:0, 18:0, 24:0) or monounsaturated acyl ...
Zhai, Xiuhong +4 more
openaire +2 more sources
Metabolites, 2022 Accurate diagnosis of colorectal cancer (CRC) still relies on invasive colonoscopy. Noninvasive methods are less sensitive in detecting the disease, particularly in the early stage.
Oiana Telleria +6 more
doaj +1 more source
Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. [PDF]
PLoS ONE, 2011 Chronic kidney disease and end-stage renal disease are major causes of morbidity and mortality that are seen far more commonly in the aged population. Interestingly, kidney function declines during aging even in the absence of underlying renal disease ...
María José Hernández-Corbacho +6 more
doaj +1 more source
Emerging Microbes and Infections, 2023 West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bites of infected mosquitoes. Severe forms of West Nile disease (WND) can curse with meningitis, encephalitis or acute flaccid paralysis.
Patricia Mingo-Casas +11 more
doaj +1 more source
Host lactosylceramide enhances Edwardsiella tarda infection
Cellular Microbiology, 2021 Edwardsiella tarda is a Gram-negative bacterium causing economic damage in aquaculture. The interaction of E. tarda with microdomains is an important step in the invasion, but the target molecules in microdomains remain undefined. Here, we found that intraperitoneal injection of E.
Kazuki Oishi +8 more
openaire +2 more sources
Biomolecules, 2023 Lipids from milk fat globule membranes (MFGMs) and extracellular vesicles (EVs) are considered beneficial for cognitive development and human health. Milk-derived whey concentrates rich in these lipids are therefore used as ingredients in infant formulas
Richard R. Sprenger +4 more
doaj +1 more source
PLoS ONE, 2020 Glycosphingolipids (GSLs) hexosylceramides and lactosylceramides are elevated in lupus mice and human patients with nephritis. Whereas other renal diseases characterized by increased GSL levels are thought to be a result of upregulated GSL synthesis, our
Tamara K Nowling +7 more
doaj +1 more source
Journal of Veterinary Internal Medicine, 2021 Background Sphingolipids modulate insulin sensitivity in mammals. Increased synthesis of ceramides is linked to decreased insulin sensitivity of tissues.
Yue Hei Leung +4 more
doaj +1 more source