Results 21 to 30 of about 862 (134)

CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism

Journal of Lipid Research, 2021
The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL isoforms (ORMDL1-3) are negative regulators of SPT.
Christopher D. Green, Cynthia Weigel, Clement Oyeniran, Briana N. James, Deanna Davis, Usha Mahawar, Jason Newton, Binks W. Wattenberg, Michael Maceyka, Sarah Spiegel   +9 more
doaj   +1 more source

The lactosylceramide binding specificity of Helicobacter pylori [PDF]

Glycobiology, 1998
The possible role of glycosphingolipids as adhesion receptors for the human gastric pathogen Helicobacter pylori was examined by use of radiolabeled bacteria, or protein extracts from the bacterial cell surface, in the thin-layer chromatogram binding assay.
J, Angström, S, Teneberg, M A, Milh, T, Larsson, I, Leonardsson, B M, Olsson, M O, Halvarsson, D, Danielsson, I, Näslund, A, Ljungh, T, Wadström, K A, Karlsson   +11 more
openaire   +2 more sources

The First Pediatric Anti-Lactosylceramide Antibody-Positive Encephalomyeloradiculoneuropathy

SSRN Electronic Journal, 2022
The anti-lactosylceramide (LacCer) antibody is an anti-neutral glycolipid antibody that is involved in the pathogenesis of encephalomyeloradiculoneuropathy (EMRN). It causes acute and subacute injuries to both the central and peripheral nerves. However, no pediatric cases of anti-LacCer antibody-positive EMRN have been reported so far.A 12-year-old ...
Akiko Sasaki, Itaru Hayakawa, Tatsuro Mutoh, Yuichi Abe   +3 more
openaire   +3 more sources

Lactosylceramide contributes to mitochondrial dysfunction in diabetes [PDF]

Journal of Lipid Research, 2016
Sphingolipids have been implicated as key mediators of cell-stress responses and effectors of mitochondrial function. To investigate potential mechanisms underlying mitochondrial dysfunction, an important contributor to diabetic cardiomyopathy, we examined alterations of cardiac sphingolipid metabolism in a mouse with streptozotocin-induced type 1 ...
Sergei A. Novgorodov, Christopher L. Riley, Jin Yu, Jarryd A. Keffler, Christopher J. Clarke, An O. Van Laer, Catalin F. Baicu, Michael R. Zile, Tatyana I. Gudz   +8 more
openaire   +3 more sources

Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration. [PDF]

J Extracell Vesicles
ABSTRACT Extracellular vesicles (EVs) represent a cytokine‐independent pathway though which skeletal muscle (SkM) cells influence the fate of neighbouring cells, thereby regulating SkM metabolic homeostasis and regeneration. Although SkM‐EVs are increasingly being explored as a therapeutic strategy to enhance muscle regeneration or to induce the ...
Hakkar R, Brun CE, Leblanc P, Meugnier E, Berger-Danty E, Blanc-Brude O, Tacconi S, Jalabert A, Reininger L, Pesenti S, Calzada C, Gache V, Vasan SB, Pichon J, Larcher T, Errazuriz-Cerda E, Cassin C, Sung BH, Weaver A, Bongiovanni A, Rouger K, de Barros JP, Bouzakri K, Rome S.   +23 more
europepmc   +2 more sources

Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils [PDF]

Glycoconjugate Journal, 2007
The neutral glycosphingolipid lactosylceramide (LacCer) forms lipid rafts (membrane microdomains) coupled with the Src family kinase Lyn on the plasma membranes of human neutrophils; ligand binding to LacCer activates Lyn, resulting in neutrophil functions, such as superoxide generation and migration (Iwabuchi and Nagaoka, Lactosylceramide-enriched ...
K. Iwabuchi, A.E.G. Prinetti, S. Sonnino, L. Mauri, T. Kobayashi, K. K. Ishii, N. Kaga, K. Murayama, H. Kurihara, H. Nakayama, F. Yoshizaki, K. Takamori, H. Ogawa, I. Nagaoka   +13 more
openaire   +3 more sources

Properties and functions of lactosylceramide from mouse neutrophils [PDF]

Glycobiology, 2015
Lactosylceramide (LacCer), which is essential for many cellular processes, is highly expressed on the plasma membranes of human neutrophils and mediates innate immune functions. Less is known, however, about the properties and biological functions of LacCer in mouse neutrophils.
Kazuhisa, Iwabuchi, Hiromi, Masuda, Naoko, Kaga, Hitoshi, Nakayama, Ryo, Matsumoto, Chihiro, Iwahara, Fumiko, Yoshizaki, Yuuki, Tamaki, Toshihide, Kobayashi, Tomohiro, Hayakawa, Kumiko, Ishii, Mitsuaki, Yanagida, Hideoki, Ogawa, Kenji, Takamori   +13 more
openaire   +2 more sources

Lactosylceramide Interacts with and Activates Cytosolic Phospholipase A2α [PDF]

Journal of Biological Chemistry, 2013
Lactosylceramide (LacCer) is a member of the glycosphingolipid family and is known to be a bioactive lipid in various cell physiological processes. However, the direct targets of LacCer and cellular events mediated by LacCer are largely unknown. In this study, we examined the effect of LacCer on the release of arachidonic acid (AA) and the activity of ...
Hiroyuki, Nakamura, Yuta, Moriyama, Tomohiko, Makiyama, Shunsuke, Emori, Hisahiro, Yamashita, Risa, Yamazaki, Toshihiko, Murayama   +6 more
openaire   +2 more sources

Contributions of amino acid, acylcarnitine and sphingolipid profiles to type 2 diabetes risk among South-Asian Surinamese and Dutch adults

BMJ Open Diabetes Research & Care, 2020
Introduction People of South Asian origin are at high risk of type 2 diabetes (T2D), but the underpinning mechanisms are not fully understood. We determined ethnic differences in acylcarnitine, amino acid and sphingolipid concentrations and determined ...
Jason M R Gill, Carlos Celis-Morales, Mirthe Muilwijk, Irene G M van Valkengoed, Frédéric M Vaz, Susan M I Goorden, Michel H Hof, Karen Ghauharali-van der Vlugt, Femke S Beers-Stet   +8 more
doaj   +1 more source

Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation [PDF]

Journal of Physiology and Biochemistry, 2020
Elastin, the major protein of the extracellular matrix, is specially found in cardiovascular tissues and contributing to 30-50% of the dry weight of blood vessels. Elastin regulates cell signalling pathways involved in morphogenesis, injury response and inflammation.
Thinhinane Hocine, Sebastien Blaise, Cathy Hachet, Alexandre Guillot, Herve Sartelet, Pascal Maurice, Amar Bennasroune, Laurent Martiny, Laurent Duca, Beatrice Romier-Crouzet, Hassan EL Btaouri   +10 more
openaire   +3 more sources