Results 61 to 70 of about 862 (134)

Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Ceramides and sphingolipids in brain development and cell compartments. Ceramides and sphingolipids are known to influence multiple steps of brain development, including the formation of the neural tube, neural stem cell polarity and proliferation at the ventricular boundary, neuronal migration—for example, whilst migrating on radial glial processes ...
Kaviya Chinnappa, Fiona Ballorin, Fiona Francis   +2 more
wiley   +1 more source

Mechanism of lactosylceramide-mediated superoxide generation in neutrophils

Ensho Saisei, 2003
Lactosylceramide (LacCer), which is neutral glycosphingolipid and also known as CDw17, mediates superoxide production from neutrophils. Microorganisms such as gram-negative and -positive bacteria and fungi can bind to LacCer. Neutrophils thus appear to contribute to phagocytosis and superoxide generation.
Kazuhisa Iwabuchi, Toshihide Kobayashi, Kumiko Ishii, Asami Makino, Naoko Kaga, Kimie Murayama, Isao Nagaoka   +6 more
openaire   +2 more sources

Beyond FimH: Diversity and Relevance of Carbohydrate‐Binding Fimbrial Proteins in Escherichia coli

ChemBioChem, Volume 26, Issue 17, September 15, 2025.
This review discusses fimbrial lectins found in Escherichia coli (E. coli) other than FimH, which could be targeted to treat E. coli pathogenicity as an alternative to antibiotic treatment. Escherichia coli (E. coli) is responsible for multiple diseases in humans and animals.
Oliwier R. Dulawa, Shane M. Coyle, Fiona Walsh, Trinidad Velasco‐Torrijos   +3 more
wiley   +1 more source

Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer's disease gene mutations in female 5xFAD mice, with brain-region specific sphingolipid alterations

Neurobiology of Disease
Pathophysiological changes associated with Alzheimer's disease (AD) begin decades before dementia onset, with age and APOE ε4 genotype as major risk factors [1–4].
Daan van Kruining, Mario Losen, Jonas Dehairs, Johannes V. Swinnen, Etienne Waelkens, Maarten Honing, Pilar Martinez-Martinez   +6 more
doaj   +1 more source

Elastin Peptides Signaling Relies on Neuraminidase-1-Dependent Lactosylceramide Generation

PLoS ONE, 2010
The sialidase activity of neuraminidase-1 (Neu-1) is responsible for ERK 1/2 pathway activation following binding of elastin peptide on the elastin receptor complex. In this work, we demonstrate that the receptor and lipid rafts colocalize at the plasma membrane.
Rusciani, A., Duca, L., Sartelet, H., Chatron-Colliet, A., Bobichon, H., Ploton, D., Naour R, Le, Blaise, S., Martiny, L., Debelle, L.   +9 more
openaire   +4 more sources

Lactosylceramide is synthesized in the lumen of the Golgi apparatus

FEBS Letters, 1994
Recently, synthesis of lactosylceramide has been described to occur on the cytosolic face of the Golgi [(1991) J. Biol. Chem. 266, 20907‐20912]. The reactions following in the biosynthesis of higher glycosphingolipids are known to take place in the lumen of the Golgi.
Lannert, Heinrich, Bünning, Garsten, Jeckel, Dieter, Wieland, Felix T.   +3 more
openaire   +2 more sources

Biosynthesis of Lactosylceramide and Triglycosylceramide by Galactosyltransferases from Rat Spleen

Journal of Biological Chemistry, 1969
Abstract The transfer of galactose from labeled uridine diphosphogalactose to glucosylceramide and to galactosyl-glucosylceramide (lactosylceramide) was shown to occur in incubations with rat spleen, brain, kidney, liver, and bone marrow preparations.
J, Hildebrand, G, Hauser
openaire   +2 more sources

Intracellular localization of lactosylceramide, the major human neutrophil glycosphingolipid.

Journal of Biological Chemistry, 1987
The abundance of lactosylceramide (LacCer; Gal beta 1-4Glc beta 1-1Cer) in human polymorphonuclear neutrophils (PMN) (about 10(9) molecules/cell) seemed inconsistent with an exclusive plasma membrane LacCer localization in these cells. Therefore, the distribution of LacCer between plasma membrane and intracellular compartments was analyzed.
F W, Symington, W A, Murray, S I, Bearman, S, Hakomori   +3 more
openaire   +2 more sources

From elastin peptides to neuraminidase-1-dependent lactosylceramide generation

Comptes Rendus. Chimie, 2011
Elastin peptides constitute a group of biologically active peptides derived from the fragmentation of insoluble elastin. These molecules, currently termed elastokines, have been shown to interact preferably with the elastin receptor complex.
Rusciani, A., Duca, L., Brassart, B., Martiny, L., Debelle, L.   +4 more
openaire   +1 more source

Sialylated lactosylceramides [PDF]

European Journal of Biochemistry, 1988
N V, Prokazova, E V, Dyatlovitskaya, L D, Bergelson   +2 more
openaire   +2 more sources