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Hypernatremia and Lactulose Therapy
JAMA: The Journal of the American Medical Association, 1983Lactulose is used in the treatment of portal-systemic encephalopathy. Although it is usually safe, a case of hypernatremia has been reported. To evaluate further the association of lactulose therapy and hypernatremia, records of patients with hepatic failure treated with lactulose for encephalopathy were analyzed.
Wallace R. G. McGrew +2 more
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Scandinavian Journal of Gastroenterology, 1997
The introduction of lactulose as a new therapeutic agent for treatment of hepatic encephalopathy was a major breakthrough in this field. It was hypothesized that lactulose might prevent postoperative renal impairment after biliary surgery in patients with obstructive jaundice.
F. J. Frey, B. Vogt
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The introduction of lactulose as a new therapeutic agent for treatment of hepatic encephalopathy was a major breakthrough in this field. It was hypothesized that lactulose might prevent postoperative renal impairment after biliary surgery in patients with obstructive jaundice.
F. J. Frey, B. Vogt
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Lactulose-Induced Hypernatremia
Drug Intelligence & Clinical Pharmacy, 1984We describe severe hypernatremia in a patient with hepatic encephalopathy, who was treated with lactulose. Lactulose produces hypernatremia via its osmotic effect and its degradation to organic acids. We recommend that patients who receive large quantities of lactulose and who lack access to free water have their electrolytes monitored and the dose ...
Amin A. Nanji, Roland W. Lauener
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The Rectal Administration of Lactulose
Australian and New Zealand Journal of Medicine, 1975Summary: A lactulose colonic washout (pH 4.5) was administered to six male patients with portal systemic encephalopathy. Estimation of blood ammonia levels and electroencephalography were performed before and after each treatment. Five patients recorded a significant fall in blood ammonia level as a result of lactulose therapy (P < 025).
E. P. Hicks +2 more
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Journal of Digestive Diseases, 2019
Lactulose is effective in the treatment and prevention of overt hepatic encephalopathy (OHE), but there are limited data on its use on microbiota in relations to minimal hepatic encephalopathy (MHE) recovery.
Ji Yao Wang +13 more
semanticscholar +1 more source
Lactulose is effective in the treatment and prevention of overt hepatic encephalopathy (OHE), but there are limited data on its use on microbiota in relations to minimal hepatic encephalopathy (MHE) recovery.
Ji Yao Wang +13 more
semanticscholar +1 more source
Can diarrhea induced by lactulose be reduced by prolonged ingestion of lactulose?
The American Journal of Clinical Nutrition, 1993Twelve healthy volunteers were studied for two test periods, at the beginning of which they ingested a diarrheogenic load (60 g) of lactulose in 350 mL water with 10 g polyethylene glycol 4000 (PEG); the two periods were separated by a lactulose feeding period of 8 d, during which a nondiarrheogenic load (20 g) of lactulose was taken twice daily.
M. Maurel +5 more
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Absorption of Lactulose in Man
Digestion, 1972Lactulose absorption was studied in 6 normal subjects after the administration of different doses of lactulose. Lactulose was detected in the blood of only one patient.
F. Manenti +2 more
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Journal of Clinical Gastroenterology, 2020
Supplemental Digital Content is available in the text. Background and Aims: Acute-on-chronic liver failure (ACLF) is associated with high short-term mortality in those with hepatic encephalopathy (HE).
Syed Ahmed +11 more
semanticscholar +1 more source
Supplemental Digital Content is available in the text. Background and Aims: Acute-on-chronic liver failure (ACLF) is associated with high short-term mortality in those with hepatic encephalopathy (HE).
Syed Ahmed +11 more
semanticscholar +1 more source
An improved colorimetric method for the estimation of lactulose in lactose-lactulose mixtures
Food Chemistry, 1992Abstract An improved colorimetric method is described for the estimation of lactulose in mixtures of lactose and lactulose. The anthrone method for the estimation of lactulose was modified by altering the concentrations of alcohol and acetic acid added to the reaction mixture.
R. Nagendra, S.Venkat Rao
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Molecular Nutrition & Food Research, 2019
SCOPE High-salt diets (HSDs) are widely considered to cause health problems such as gut microecological imbalances, constipation, and hypertension. This study explores how lactulose as a safe molecule can stimulate bodily responses to alleviate salt ...
Zheng Zhang +11 more
semanticscholar +1 more source
SCOPE High-salt diets (HSDs) are widely considered to cause health problems such as gut microecological imbalances, constipation, and hypertension. This study explores how lactulose as a safe molecule can stimulate bodily responses to alleviate salt ...
Zheng Zhang +11 more
semanticscholar +1 more source